Efficient access to multi-substituted 1-aminoisoquinolines via Rh(III)- catalyzed oxidative annulation of aminopyridine pivalamides with internal alkynes

被引：0
|
作者：
Gan, Xiaoting [1 ]
Huang, Fen [1 ]
Ren, Zhijun [1 ]
Li, Bo [2 ]
Chen, Shaojie [1 ]
Luo, Wenkun [1 ]
Zhou, Jun [1 ]
机构：
[1] Changsha Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Mat Protect Elect Power & Trans, Changsha 410114, Peoples R China
[2] Zhejiang NHU Co Ltd, Shaoxing 312500, Peoples R China
来源：
TETRAHEDRON LETTERS | 2022年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Rhodium; C-H activation; Annulation; Aminopyridine; Isoquinoline; C-H ACTIVATION; ONE-POT SYNTHESIS; ISOQUINOLINE DERIVATIVES; FUNCTIONALIZATION; RING; BENZANNULATION; PICOLINAMIDES; INHIBITORS; MULTIPLE; AMIDINES;
D O I：
10.1016/j.tetlet.2022.153970
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of multi-substituted 1-aminoisoquinolines from aminopyridine pivalamides with alkynes by Rh(III)-catalyzed C-H activation coupling has been investigated. This method proved to be tolerant of synthetically versatile functional groups, and provided access to a few highly substituted isoquinoline derivatives with remarkable fluorescence properties in moderate yields.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：7
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