Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells

被引：29

作者：

Duman, Fatma Demir ^{[1
]}

Erkisa, Merve ^{[2
]}

Khodadust, Rouhullah ^{[1
]}

Ari, Ferda ^{[2
]}

Ulukaya, Engin ^{[3
]}

Acar, Havva Yagci ^{[1
,4
]}

机构：

[1] Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey

[2] Uludag Univ, Dept Biol, TR-16059 Bursa, Turkey

[3] Istinye Univ, Sch Med, Dept Clin Biochem, TR-34010 Istanbul, Turkey

[4] Koc Univ, Surface Sci & Technol Ctr KUYTAM, TR-34450 Istanbul, Turkey

来源：

NANOMEDICINE | 2017年 / 12卷 / 19期

关键词：

Ag2S quantum dots; cancer therapy; doxorubicin; near-infrared imaging; targeting; DRUG-DELIVERY; HIGHLY LUMINESCENT; CYTOTOXICITY; FOLATE; CARDIOTOXICITY; NANOPARTICLES; APOPTOSIS; ASSAY; TOOL;

D O I：

10.2217/nnm-2017-0180

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.

引用

页码：2319 / 2333

页数：15

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