FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma

被引：77

作者：

Ai, Jianzhong ^{[1
]}

Huang, Huizhe ^{[3
]}

Lv, Xiaoyan ^{[4
]}

Tang, Ziwei

Chen, Mianzhi ^{[1
]}

Chen, Tielin ^{[1
]}

Duan, Weiwei ^{[1
]}

Sun, Huan ^{[1
]}

Li, Qingwei ^{[1
]}

Tan, Ruizhi ^{[1
]}

Liu, Yuhang ^{[1
]}

Duan, Jingjing ^{[1
]}

Yang, Yang ^{[1
]}

Wei, Yuquan ^{[1
]}

Li, Yan ^{[5
,6
]}

Zhou, Qin ^{[1
,2
]}

机构：

[1] Sichuan Univ, Core Facil Genetically Engn Mice, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Med Sch, W China Hosp, Ctr Canc, Chengdu 610041, Peoples R China

[3] Chongqing Med Univ, Sch Basic Med, Core Facil Zebrafish Res, Chongqing, Peoples R China

[4] Sichuan Univ, W China Med Sch, W China Hosp, Dept Dermatol, Chengdu 610041, Peoples R China

[5] Wuhan Univ, Zhongnan Hosp, Dept Oncol, Wuhan 430072, Peoples R China

[6] Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2011年 / 27卷 / 3-4期

关键词：

FLNA; PGK1; Hepatocellular Carcinoma; ESI-Q-TOF MS/MS; Biomarkers; IN-VIVO SELECTION; PROSTATE-CANCER; GASTRIC-CANCER; CELL-LINE; METASTATIC CHARACTERISTICS; MESSENGER-RNA; UNITED-STATES; EXPRESSION; FILAMIN; MIGRATION;

D O I：

10.1159/000327946

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background/Aims: Hepatocellular carcinoma (HCC) is one of the most deadly diseases; metastasis and recurrence are the most important factors that affect the therapy of HCC chronically. Until now, the prognosis for the metastasis of HCC had not improved. Recently, several proteins that are related to metastasis and invasion of HCC were identified, but the effective markers still remain to be elucidated. Methods: In this study, comparative proteomics was used to study the differentially expressed proteins in two HCC cell lines MHCC97L and HCCLM9, which have low and high metastatic potentials, respectively. Results: Our findings indicated that filamin A (FLNA) and phosphoglycerate kinase 1 (PGK1) were two significantly differentially expressed proteins, with high expression in HCCLM9 cells, and may influence the metastasis of HCC cells. Conclusion: Taken together with the confirmation of expression on the mRNA level, we propose the use of FLNA and PGK1 as potential markers for the progression of HCC. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：207 / 216

页数：10

共 42 条

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