Antitumor Effects of JAK3 Inhibitor on the Model of Transplantable Lewis Lung Carcinoma and Mechanisms of Their Development

被引：6

作者：

Zyuz'kov, G. N. ^{[1
,2
]}

Amosova, E. N. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Udut, E. V. ^{[1
]}

Rybalkina, O. Yu. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

Dygai, A. M. ^{[1
]}

Zueva, E. P. ^{[1
]}

机构：

[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia

[2] Natl Res Tomsk State Univ, Lab Phys Proc Modeling Biol & Med, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 03期

关键词：

tumor diseases; targeted therapy; intracellular signaling; JAK; cancer stem cells; PROGENITOR CELLS;

D O I：

10.1007/s10517-016-3415-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mice with Lewis lung carcinoma were used to study the antitumor and antimetastatic effects of JAK3 inhibitor. The study revealed no effect of JAK3 inhibitor on the growth of primary tumor node, but found a pronounced inhibition of hematogenous spread of the pathologic process into the lungs. In vitro blockade of JAK3 in cultured Lewis lung carcinoma produced no effect on the count of the stem tumor cells and stimulated functions of committed elements. In addition, blockade of JAK3 significantly elevated maturation index of the tumor tissue.

引用

页码：367 / 370

页数：4

共 15 条

[1] Sunitinib (SU11248) in patients with chemo naive extensive small cell lung cancer or who have a 'chemosensitive' relapse: A single-arm phase II study (EORTC-08061) [J].

Abdelraouf, Fatma ;

Smit, Egbert ;

Hasan, Baktiar ;

Menis, Jessica ;

Popat, Sanjay ;

van Meerbeeck, Jan P. ;

Surmont, Veerle F. ;

Baas, Paul ;

O'Brien, Mary .

EUROPEAN JOURNAL OF CANCER, 2016, 54 :35-39

[2]

[Чиссов В.И. Chissov V.I.], 2006, [Российский биотерапевтический журнал, Rossiiskii bioterapevticheskii zhurnal], V5, P7

[3] Effect of Hyaluronidase Immobilized Using Electron-Beam Synthesis Nanotechnology on Sensitivity of Progenitor Cells to Regulatory Factors [J].

Dygai, A. M. ;

Zyuz'kov, G. N. ;

Zhdanov, V. V. ;

Udut, E. V. ;

Miroshnichenko, L. A. ;

Khrichkova, T. Yu ;

Simanina, E. V. ;

Stavrova, L. A. ;

Chaikovskiy, A. V. ;

Markova, T. S. ;

Minakova, M. Yu ;

Gol'dberg, V. E. ;

Artamonov, A. V. ;

Bekarev, A. A. ;

Madonov, P. G. ;

Kinsht, D. N. ;

Gurto, R. V. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 151 (01) :150-153

[4]

Gorbunov VA, 2015, GUIDELINES CHEMOTHER

[5] JAKS AND STATS: Biological implications [J].

Leonard, WJ ;

O'Shea, JJ .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :293-322

[6] Tumor Clonality: Research and Clinical Aspects [J].

Nemtsova, M. V. ;

Kushlinskii, N. E. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2014, 158 (02) :246-251

[7]

Novik AA, 2004, INTRO MOL BIOL CANCE

[8] Evidence for Janus kinase (JAK) inhibitors for the prevention of major morbid events in patients with myeloproliferative neoplasms (MPNs) [J].

Pemmaraju, Naveen ;

Mesa, Ruben .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2015, :649-651

[9] Effects of Nonstarch Polysaccharides with Different Molecular Weights on the Development of Lewis Lung Carcinoma in Mice and Efficiency of Cytostatic Therapy [J].

Rybalkina, O. Yu. ;

Razina, T. G. ;

Lopatina, K. A. ;

Amosova, E. N. ;

Krylova, S. G. ;

Efimova, L. A. ;

Safonova, E. A. ;

Zueva, E. P. ;

Khotimchenko, M. Yu. ;

Khotimchenko, Yu. S. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2013, 154 (04) :492-496

[10] JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms [J].

Schoenberg, Kathrin ;

Rudolph, Janna ;

Vonnahme, Maria ;

Yajnanarayana, Sowmya Parampalli ;

Cornez, Isabelle ;

Hejazi, Maryam ;

Manser, Angela R. ;

Uhrberg, Markus ;

Verbeek, Walter ;

Koschmieder, Steffen ;

Bruemmendorf, Tim H. ;

Brossart, Peter ;

Heine, Annkristin ;

Wolf, Dominik .

CANCER RESEARCH, 2015, 75 (11) :2187-2199

← 1 2 →