Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

被引：10

作者：

Qin, Xuan ^{[1
,3
]}

Poon, Brian ^{[1
]}

Kwong, Justin ^{[1
]}

Niles, Denver ^{[1
]}

Schmidt, Byron Z. ^{[2
]}

Rajagopal, Lakshmi ^{[2
,4
]}

Gantt, Soren ^{[4
]}

机构：

[1] Seattle Childrens Hosp, Microbiol Lab, Seattle, WA 98105 USA

[2] Seattle Childrens Hosp, Res Inst, Seattle, WA 98105 USA

[3] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA

[4] Univ Washington, Sch Med, Dept Pediat, Div Infect Dis, Seattle, WA 98195 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2011年 / 38卷 / 01期

关键词：

Staphylococcus aureus; Clindamycin; Efflux pump; STREPTOGRAMIN; SUSCEPTIBILITY; PROTEINS; GENES;

D O I：

10.1016/j.ijantimicag.2011.03.007

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates. (C) 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：81 / 83

页数：3