Antibodies specific for heat shock proteins in human and murine malaria

被引：23
作者：
Zhang, MX
Hisaeda, H
Kano, S
Matsumoto, Y
Hao, YP
Looaresuwan, S
Aikawa, M
Himeno, K [1 ]
机构：
[1] Univ Tokushima, Sch Med, Dept Parasitol & Immunol, Tokushima 7708503, Japan
[2] Gunma Univ, Sch Med, Dept Parasitol, Gunma, Japan
[3] Univ Tokyo, Sch Agr & Life Sci, Dept Mol Immunol, Tokyo, Japan
[4] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand
[5] Mahidol Univ, Res Inst Med Sci, Kanagawa, Japan
来源：
MICROBES AND INFECTION | 2001年 / 3卷 / 05期
关键词：
malaria; heat shock protein; antibody;
D O I：
10.1016/S1286-4579(01)01391-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Heat shock proteins (HSPs) are immunodominant antigens recognized by the host immune system in various infectious diseases. We analyzed HSP-specific antibodies, including immunoglobulin G (IgG), IgM and IgA, in sera from malaria patients in Thailand by using an enzyme-linked immunosorbent assay. All of the antibodies to HSP90 were remarkably increased in the patients compared with those in controls, while only IgM to HSP70 or IgA to HSP65 was significantly elevated. Further experiments showed that anti-HSP IgG was significantly increased in C57BL/6 mice infected with a non-lethal strain of plasmodium yoelii, with anti-HSP90 IgG being the most elevated. These results suggest that the antigenic potential of HSP90 is higher than those of HSP70 and HSP65 in malaria infection. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：363 / 367
页数：5
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