Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

被引：5

作者：

Paidi, Karuna Raman ^{[1
]}

Kolli, Murali Krishna ^{[1
]}

Reddy, Eeda Koti ^{[2
]}

Pedakotla, Venkata Ramana ^{[1
]}

机构：

[1] Sri Krishnadevaraya Univ, Anantapur 515003, Andhra Pradesh, India

[2] Vignans Fdn Sci Technol & Res Deemed Be Univ, Guntur Tenali Rd, Vadlamudi 522213, Andhra Pradesh, India

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 03期

关键词：

N-acylhydrazone; aldehyde; hydrazide; oxadiazole; sodium hypochlorite; oxidative cyclization; ONE-POT SYNTHESIS; OXIDATIVE CYCLIZATION; SUBSTITUTED 1,3,4-OXADIAZOLES; FUNGICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; ACID HYDRAZIDES; GREEN SYNTHESIS; OXADIAZOLE; DERIVATIVES; DESIGN;

D O I：

10.1007/s10593-020-02669-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

引用

页码：371 / 376

页数：6

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