Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome

被引:3
作者
Fabis-Pedrini, Marzena J. [1 ,2 ]
Kuhle, Jens [3 ,4 ]
Roberts, Katherine M. A. [1 ]
Trend, Stephanie [1 ,5 ]
Jones, Anderson P. [5 ]
Maceski, Aleksandra [3 ,4 ]
Carroll, William M. [1 ]
Lucas, Robyn M. [6 ,7 ]
Mastaglia, Frank L. [1 ,2 ]
Hart, Prue H. [5 ]
Kermode, Allan G. [1 ,2 ,8 ]
机构
[1] Univ Western Australia, Perron Inst Neurol & Translat Sci, Perth, WA, Australia
[2] Murdoch Univ, Ctr Mol Med & Innovat Therapeut, Perth, WA, Australia
[3] Univ Basel, Neurol Clin & Policlin, MS Ctr, Basel, Switzerland
[4] Univ Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel, Basel, Switzerland
[5] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia
[6] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Res Sch Populat Hlth, Canberra, ACT, Australia
[7] Univ Western Australia, Ctr Ophthalmol & Visual Sci, Perth, WA, Australia
[8] Murdoch Univ, Inst Immunol & Infect Dis, Perth, WA, Australia
来源
BRAIN AND BEHAVIOR | 2022年 / 12卷 / 02期
基金
英国医学研究理事会;
关键词
clinically isolated syndrome; lesion volume; multiple sclerosis; neurofilament light chain; ultraviolet B;
D O I
10.1002/brb3.2494
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB-PT). Methods sNfL levels were measured using a sensitive single-molecule array assay at baseline and up to 12 months in 17 patients with CIS, 10 of whom received UVB-PT, and were compared with healthy control (HC) and early relapsing remitting multiple sclerosis (RRMS) group. sNfL levels were correlated with magnetic resonance imaging total lesion volume (LV) determined using icobrain version 4.4.1 and with clinical outcomes. Results Baseline median sNfL levels were significantly higher in the CIS (20.6 pg/mL, interquartile range [IQR] 13.7-161.4) and RRMS groups (36.6 pg/ml [IQR] 16.2-212.2) than in HC (10.7 pg/ml [IQR] 4.9-21.5) (p = .012 and p = .0002, respectively), and were strongly correlated with T2 and T1 LV at 12 months (r = .800; p = .014 and r = .833; p = .008, respectively) in the CIS group. Analysis of changes in sNfL levels over time in the CIS group showed a significant cumulative suppressive effect of UVB-PT in the first 3 months (UVB-PT -10.6% vs non-UVB-PT +58.3%; p = .04) following which the levels in the two groups converged and continued to fall. Conclusions Our findings provide the basis for further studies to determine the utility of sNfL levels as a marker of neuro-axonal damage in CIS and early MS and for assessing the efficacy of new therapeutic interventions such as UVB-PT.
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页数:5
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