A System Bioinformatics Approach Predicts the Molecular Mechanism Underlying the Course of Action of Radix Salviae Reverses GBM Effects

被引:1
作者
Sun Jiaojiao [1 ]
He Yuping [1 ]
Li Yajuan [2 ]
Liu Guangyi [1 ]
Li Qiuhong [1 ]
Li Shengbiao [1 ]
Yu Hong [1 ]
机构
[1] Southwest Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Luzhou 646000, Sichuan, Peoples R China
[2] Chongqing Med Univ, Yongchuan Hosp, Chongqing 402160, Peoples R China
关键词
CELL-PROLIFERATION; GLIOBLASTOMA CELLS; MIGRATION; U251; EXPRESSION; INVASION; PATHWAY; GROWTH; GLIOMA; U87;
D O I
10.1155/2021/1218969
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Objective. This study used in vitro techniques to investigate the therapeutic effect of Radix Salviae on human glioblastoma and decode its underlying molecular mechanism. Methods. The active components and targets of the Radix Salviae were identified from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP). The targets of human glioblastoma were obtained from the GeneCards Database. The Radix Salviae-mediated antiglioblastoma was evaluated by Gene Ontology (GO) analyses and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Finally, mechanism of action of Radix Salviae against human glioblastoma was deduced by molecular docking and experiments. Results. We screened 66 active ingredients and 45 targets of the Radix Salviae. The enrichment analysis based on the targets mentioned above suggested a possible role in protein phosphorylation, cell transcription, apoptosis, and inflammatory factor signaling pathways. Further study demonstrated that cryptotanshinone, an essential component of Radix Salviae, played a significant role in killing human glioblastoma cells and protecting the body by inhibiting the AKT, IKB, and STAT3 signaling pathways. Conclusions. Radix Salviae could inhibit the proliferation and invasion of human glioblastoma by regulating STAT3, Akt, and IKB signaling pathways. Radix Salviae has potential therapeutic value in the future for human glioblastoma.
引用
收藏
页数:12
相关论文
共 49 条
[21]   Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population [J].
Lin, R. P. ;
Yao, C. Y. ;
Ren, D. X. .
GENETICS AND MOLECULAR RESEARCH, 2015, 14 (02) :3142-3148
[22]   Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases [J].
Liu, Hongbin ;
Zhan, Xiaoyan ;
Xu, Guang ;
Wang, Zhilei ;
Li, Ruisheng ;
Wang, Yan ;
Qin, Qin ;
Shi, Wei ;
Hou, Xiaorong ;
Yang, Ruichuang ;
Wang, Jian ;
Xiao, Xiaohe ;
Bai, Zhaofang .
PHARMACOLOGICAL RESEARCH, 2021, 164
[23]   Systems approaches and polypharmacology for drug discovery from herbal medicines: An example using licorice [J].
Liu, Hui ;
Wang, Jinan ;
Zhou, Wei ;
Wang, Yonghua ;
Yang, Ling .
JOURNAL OF ETHNOPHARMACOLOGY, 2013, 146 (03) :773-793
[24]   Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective [J].
Luo, Ting-ting ;
Lu, Yuan ;
Yan, Shi-kai ;
Xiao, Xue ;
Rong, Xiang-lu ;
Guo, Jiao .
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2020, 26 (01) :72-80
[25]   Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells [J].
Maiti, Panchanan ;
Scott, Jason ;
Sengupta, Dipanwita ;
Al-Gharaibeh, Abeer ;
Dunbar, Gary L. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (02)
[26]   Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy [J].
Mannelli, Lorenzo Di Cesare ;
Piccolo, Marialuisa ;
Maione, Francesco ;
Ferraro, Maria Grazia ;
Irace, Carlo ;
De Feo, Vincenzo ;
Ghelardini, Carla ;
Mascolo, Nicola .
BIOMEDICINE & PHARMACOTHERAPY, 2018, 105 :1042-1049
[27]   The Viral Connection to Glioblastoma [J].
McFaline-Figueroa, J. Ricardo ;
Wen, Patrick Y. .
CURRENT INFECTIOUS DISEASE REPORTS, 2017, 19 (02)
[28]   Recent advances in targeted therapy for glioblastoma [J].
Mittal, Shivani ;
Pradhan, Shrikant ;
Srivastava, Tapasya .
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2015, 15 (08) :935-946
[29]   Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand [J].
Oh, Se-Jeong ;
Yang, Jung-In ;
Kim, Ok ;
Ahn, Eun-Jung ;
Kang, Woo Dae ;
Lee, Jae-Hyuk ;
Moon, Kyung-Sub ;
Lee, Kyung-Hwa ;
Cho, Duck .
CANCER CELL INTERNATIONAL, 2017, 17
[30]   The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma [J].
Ozyerli-Goknar, Ezgi ;
Sur-Erdem, Ilknur ;
Seker, Fidan ;
Cingoz, Ahmet ;
Kayabolen, Alisan ;
Kahya-Yesil, Zeynep ;
Uyulur, Firat ;
Gezen, Melike ;
Tolay, Nazife ;
Erman, Batu ;
Gonen, Mehmet ;
Dunford, James ;
Oppermann, Udo ;
Bagci-Onder, Tugba .
CELL DEATH & DISEASE, 2019, 10 (12)