Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients

被引：1

作者：

Boldrini, Laura ^{[1
]}

Gisfredi, Silvia ^{[1
]}

Ursino, Silvia ^{[1
]}

Lucchi, Marco ^{[2
]}

Greco, Giordana ^{[1
]}

Mussi, Alfredo ^{[2
]}

Fontanini, Gabriella ^{[1
]}

机构：

[1] Univ Pisa, Dept Surg, I-56100 Pisa, Italy

[2] Univ Pisa, Dept Cardio Thorac Surg, I-56100 Pisa, Italy

来源：

ONCOLOGY REPORTS | 2008年 / 19卷 / 03期

关键词：

TP53 Arg72Pro polymorphism; non-small cell lung cancer; prognosis;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations of the p53 gene represent the most common genetic alterations in human cancer. Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid. Polymorphisms at codon 72 of the p53 gene were determined using a PCR-RFLP-based method. We analysed the relationship of this polymorphism to patient survival in 121 non-small cell lung cancer (NSCLC) cases. Interestingly, the 72P homozygous NSCLC patients often presented high-grade tumours and had significantly poorer survival rates than patients with R72 homozygotes or heterozygotes. Our results may help clarify discrepancies in the literature concerning the prognostic role of p53 codon 72 variants.

引用

页码：771 / 773

页数：3

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