The Effects of Lactic Acid in Tumor Microenvironment

被引：0
|
作者：
Koncosova, Martina [1 ,2 ]
Ruml, Tomas [1 ,2 ]
Zelenka, Jaroslav [1 ,2 ]
机构：
[1] Vysoka Skola Chem Technol, Ustav Biochem & Mikrobiol, Tech 3, Prague 16628 6, Czech Republic
[2] Univ Chem & Technol Prague, Dept Biochem & Microbiol, Prague, Czech Republic
来源：
CHEMICKE LISTY | 2020年 / 114卷 / 05期
关键词：
lactate; lactic acid; acidosis; tumor microenvironment; therapy; HIGH LACTATE LEVELS; MONOCARBOXYLATE TRANSPORTERS; CANCER; ANGIOGENESIS; METABOLISM; CELLS; DEHYDROGENASE; INHIBITION; PREVENTION; MOLECULE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Malignant transformation of the cells leads to a change in their metabolism, characterized mainly by increased glucose uptake and its conversion to lactic acid, which has a significant signaling role in the tumor microenvironment. Lactic acid is important for energy cell metabolism: it has an immunosuppressive role, can promote angiogenesis, repair mechanisms, invasiveness, and metastasis. The study of therapeutic opportunities of targeting lactic acid metabolism currently represents an outstandingly exposed field of research that could contribute to improving the prognosis of cancer patients.
引用
收藏
页码：336 / 340
页数：5
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