Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies

被引：5
作者：
Kandagatla, Pridvi [1 ]
Maguire, Lilias H. [2 ]
Hardiman, Karin M. [2 ]
机构：
[1] Wayne State Univ, Dept Surg, Henry Ford Hlth Syst, Detroit, MI USA
[2] Univ Michigan, Dept Surg, Div Colorectal Surg, Ann Arbor, MI 48109 USA
来源：
EUROPEAN SURGICAL RESEARCH | 2018年 / 59卷 / 5-6期
关键词：
Colorectal cancer; Cancer genetics; Lymph node metastasis; Intratumor heterogeneity; COLORECTAL-CANCER; LYMPH-NODE; INTRATUMOR HETEROGENEITY; METASTASIS; EVOLUTION; EXPRESSION; KRAS; PROGRESSION; MUTATIONS; THERAPY;
D O I：
10.1159/000494832
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy. (c) 2018 S. Karger AG, Basel
引用
收藏
页码：361 / 370
页数：10
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