LC-APCI-MS Quantitative Analysis of Curcumin in Rabbit Plasma

被引：19
|
作者：
Yang, Xuezhi [3 ]
Ma, Jianshe [2 ]
Ye, Yun [1 ]
Zhang, Yuan [1 ]
Lin, Guanyang [3 ]
Zheng, Yuancai [3 ]
Li, Xu [2 ]
Wang, Xianqin [1 ]
机构：
[1] Wenzhou Med Coll, Analyt & Testing Ctr, Wenzhou 325035, Peoples R China
[2] Wenzhou Med Coll, Sch Basic Med Sci, Wenzhou 325035, Peoples R China
[3] Wenzhou Med Coll, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
来源：
CHROMATOGRAPHIA | 2011年 / 73卷 / 5-6期
关键词：
Column liquid chromatography; APCI; Curcumin; Plasma; PERFORMANCE LIQUID-CHROMATOGRAPHY; RAT PLASMA; ASSAY;
D O I：
10.1007/s10337-011-1918-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple and specific liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) method was developed and validated for quantitative analysis of curcumin in rabbit plasma. Chromatographic separation was carried out on Zorbax SB-C18 column, acetonitrile-methanol-water used as mobile phase with gradient elution. APCI source was applied and operated in negative ion mode, and selective ion monitoring mode used to quantify curcumin. The method showed excellent intra-assay and inter-assay precision (relative standard deviations and bias < 15%) for quality control (QC) samples. This method was successfully applied to a pharmacokinetic study of curcumin after intravenous administration to rabbits.
引用
收藏
页码：605 / 608
页数：4
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