Tracing Spatiotemporal T790M Heterogeneity in Patients with EGFR-Mutant Advanced NSCLC after Acquired Resistance to EGFR TKIs

被引:0
|
作者
Zhang, Yi-Chen
Pi, Can
Ke, E-E
Chen, Zhi-Hong
Su, Jian
Dong, Zhong-Yi
Xu, Chong-Rui
Tu, Hai-Yan
Yan, Hong-Hong
Zhong, Wen-Zhao
Yang, Jin-Ji
Zhang, Xu-Chao
Wu, Yi Long
Zhou, Qing
机构
[1] Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China
[2] GGH, Guangzhou, Guangdong, Peoples R China
[3] Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China
关键词
Acquired resistance; EGFR TKIs; spatiotemporal heterogeneity; T790M;
D O I
10.1016/j.jtho.2016.11.1762
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P3.02b-095
引用
收藏
页码:S1249 / S1249
页数:1
相关论文
共 50 条
  • [41] Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance
    Wang, Ying
    Liu, Qiuyun
    Chen, Haojie
    You, Jun
    Peng, Bin
    Cao, Fanfan
    Zhang, Xue
    Chen, Qing
    Uzan, Georges
    Xu, Limin
    Zhang, Denghai
    ANTI-CANCER DRUGS, 2018, 29 (08) : 748 - 755
  • [42] Differential prognostic value of tumor and plasma T790M mutations in EGFR TKI-treated advanced NSCLC
    Tung, Pi-Hung
    Chiu, Tzu-Hsuan
    Huang, Allen Chung-Cheng
    Ju, Jia-Shiuan
    Huang, Chi-Hsien
    Wang, Chin-Chou
    Ko, How-Wen
    Chung, Fu-Tsai
    Hsu, Ping-Chih
    Fang, Yueh-Fu
    Guo, Yi-Ke
    Kuo, Chih-Hsi Scott
    Yang, Cheng-Ta
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2024, 16
  • [43] Overcoming acquired resistance of EGFR-mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib, with the natural product honokiol
    Zang, Hongjing
    Qian, Guoqing
    Arbiser, Jack
    Owonikoko, Taofeek K.
    Ramalingam, Suresh S.
    Fan, Songqing
    Sun, Shi-Yong
    MOLECULAR ONCOLOGY, 2020, 14 (04) : 882 - 895
  • [44] Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer
    Cheng, Ningning
    Cai, Weijing
    Ren, Shengxiang
    Li, Xuefei
    Wang, Qi
    Pan, Hui
    Zhao, Mingchuan
    Li, Jiayu
    Zhang, Yishi
    Zhao, Chao
    Chen, Xiaoxia
    Fei, Ke
    Zhou, Caicun
    Hirsch, Fred R.
    ONCOTARGET, 2015, 6 (27) : 23582 - 23593
  • [45] Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells
    Wu, Hong
    Wang, Aoli
    Zhang, Wei
    Wang, Beilei
    Chen, Cheng
    Wang, Wenchao
    Hu, Chen
    Ye, Zi
    Zhao, Zheng
    Wang, Li
    Li, Xixiang
    Yu, Kailin
    Liu, Juan
    Wu, Jiaxin
    Yan, Xiao-E
    Zhao, Peng
    Wang, Jinhua
    Wang, Chu
    Weisberg, Ellen L.
    Gray, Nathanael S.
    Yun, Cai-Hong
    Liu, Jing
    Chen, Liang
    Liu, Qingsong
    ONCOTARGET, 2015, 6 (31) : 31313 - 31322
  • [46] The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment
    Demuth, Christina
    Madsen, Anne Tranberg
    Weber, Britta
    Wu, Lin
    Meldgaard, Peter
    Sorensen, Boe Sandahl
    BMC CANCER, 2018, 18
  • [47] Comprehensive analysis of EGFR T790M detection by ddPCR and ARMS-PCR and the effect of mutant abundance on the efficacy of osimertinib in NSCLC patients
    Li, Yue
    Xu, Yuxia
    Wu, Xiaoyan
    He, Caiyun
    Liu, Qing
    Wang, Fang
    JOURNAL OF THORACIC DISEASE, 2019, 11 (07) : 3004 - +
  • [48] Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib
    Hochmair, Maximilian J.
    Buder, Anna
    Schwab, Sophia
    Burghuber, Otto C.
    Prosch, Helmut
    Hilbe, Wolfgang
    Cseh, Agnieszka
    Fritz, Richard
    Filipits, Martin
    TARGETED ONCOLOGY, 2019, 14 (01) : 75 - 83
  • [49] Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non-small-cell Lung Cancer
    Kawamura, Takahisa
    Kenmotsu, Hirotsugu
    Omori, Shota
    Nakashima, Kazuhisa
    Wakuda, Kazushige
    Ono, Akira
    Naito, Tateaki
    Murakami, Haruyasu
    Omae, Katsuhiro
    Mori, Keita
    Tanigawara, Yusuke
    Nakajima, Takashi
    Ohde, Yasuhisa
    Endo, Masahiro
    Takahashi, Toshiaki
    CLINICAL LUNG CANCER, 2018, 19 (02) : E247 - E252
  • [50] Acquired Resistance to Third-Generation EGFR Tyrosine Kinase Inhibitors in Patients With De Novo EGFRT790M-Mutant NSCLC
    Park, Ha-Ram
    Kim, Tae Min
    Lee, Yusoo
    Kim, Soyeon
    Park, Seongyeol
    Ju, Young Seok
    Kim, Miso
    Keam, Bhumsuk
    Jeon, Yoon Kyung
    Kim, Dong-Wan
    Heo, Dae Seog
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (11) : 1859 - 1871