Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis

被引：33
作者：
Han, Huajun [1 ,2 ,3 ]
Safe, Stephen [3 ,4 ]
Jayaraman, Arul [5 ]
Chapkin, Robert S. [1 ,2 ,3 ]
机构：
[1] Texas A&M Univ, Program Integrat Nutr & Complex Dis, College Stn, TX 77843 USA
[2] Texas A&M Univ, Dept Nutr, College Stn, TX 77843 USA
[3] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA
[4] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA
[5] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA
来源：
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021 | 2021年 / 41卷
基金：
美国国家卫生研究院;
关键词：
aryl hydrocarbon receptor; gut microbiota; ligands; inflammatory bowel disease; colon cancer; SULFATE-INDUCED COLITIS; GUT MICROBIOTA; AH RECEPTOR; TRYPTOPHAN-METABOLISM; BARRIER FUNCTION; T-CELLS; INFLAMMATION; INDOLE; ACTIVATION; INDUCTION;
D O I：
10.1146/annurev-nutr-043020-090050
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helixloop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement of health-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.
引用
收藏
页码：455 / 478
页数：24
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