Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis

被引：38

作者：

Han, Huajun ^{[1
,2
,3
]}

Safe, Stephen ^{[3
,4
]}

Jayaraman, Arul ^{[5
]}

Chapkin, Robert S. ^{[1
,2
,3
]}

机构：

[1] Texas A&M Univ, Program Integrat Nutr & Complex Dis, College Stn, TX 77843 USA

[2] Texas A&M Univ, Dept Nutr, College Stn, TX 77843 USA

[3] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

[4] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA

[5] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA

来源：

ANNUAL REVIEW OF NUTRITION, VOL 41, 2021 | 2021年 / 41卷

基金：

美国国家卫生研究院;

关键词：

aryl hydrocarbon receptor; gut microbiota; ligands; inflammatory bowel disease; colon cancer; SULFATE-INDUCED COLITIS; GUT MICROBIOTA; AH RECEPTOR; TRYPTOPHAN-METABOLISM; BARRIER FUNCTION; T-CELLS; INFLAMMATION; INDOLE; ACTIVATION; INDUCTION;

D O I：

10.1146/annurev-nutr-043020-090050

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helixloop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement of health-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.

引用

页码：455 / 478

页数：24

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