The Role of Microglia in Neurodevelopmental Disorders and their Therapeutics

被引：20

作者：

Coomey, Rachel ^{[1
]}

Stowell, Rianne ^{[2
]}

Majewska, Ania ^{[2
]}

Tropea, Daniela ^{[3
,4
]}

机构：

[1] Trinity Coll Dublin, Trinity Coll, Sch Med, Trinity Biomed Sci Inst, Level 1,152-160 Pearse St, Dublin D02 R590 2, Ireland

[2] Univ Rochester, Dept Neurosci, 601 Elmwood Ave Box 603, Rochester, NY 14642 USA

[3] St James Hosp, Trinity Ctr Hlth Sci, Trinity Translat Med Inst, Trinity Coll Dublin,Neuropsychiat Genet, Dublin D08 W9RT 8, Ireland

[4] RCSI, FutureNeuro SFI Res Ctr, 123 St Stephens Green, Dublin D02 YN77 2, Ireland

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

Microglia; Neurodevelopmental disorders; Therapeutics; Genetic; Pathophysiology; Immune cells; WILD-TYPE MICROGLIA; RETT-SYNDROME; ACTIVATION; PATHOLOGY; BRAIN;

D O I：

10.2174/1568026620666200221172619

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of new therapeutics is critically dependent on an understanding of the molecular pathways, the disruption of which results in neurological symptoms. Genetic and biomarker studies have highlighted immune signalling as a pathway that is impaired in patients with neurodevelopmental disorders (NDDs), and several studies on animal models of aberrant neurodevelopment have implicated microglia, the brain's immune cells, in the pathology of these diseases. Despite the increasing awareness of the role of immune responses and inflammation in the pathophysiology of NDDs, the testing of new drugs rarely considers their effects in microglia. In this brief review, we present evidence of how the study of microglia can be critical for understanding the mechanisms of action of candidate drugs for NDDs and for increasing their therapeutic effect.

引用

页码：272 / 276

页数：5

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