Role of CD20 expression and other pre-treatment risk factors in the development of infusion-related reactions in patients with CLL treated with obinutuzumab

被引：21
作者：
Freeman, C. L. [1 ]
Dixon, M. [2 ]
Houghton, R. [3 ]
Kreuzer, K-A [4 ,5 ]
Fingerle-Rowson, G. [6 ]
Herling, M. [4 ,5 ]
Humphrey, K. [7 ]
Boettcher, S. [8 ]
de Costa, C. S. [9 ]
Iglesias, V. [9 ]
Stilgenbauer, S. [10 ]
Gribben, J. [1 ]
Hallek, M. [4 ,5 ,11 ,12 ]
Goede, V. [4 ,5 ,11 ,12 ]
机构：
[1] Queen Mary Univ London, John Vane Canc Ctr, Barts Canc Inst, Dept Haematooncol, Charterhouse Sq, London, England
[2] Roche Prod Ltd, Dept Biostat, Welwyn Garden City, Herts, England
[3] Roche Prod Ltd, Dept Stat Programming & Anal, Welwyn Garden City, Herts, England
[4] German CLL Study Grp, Ctr Integrated Oncol Cologne, Bonn, Germany
[5] Univ Hosp Cologne, Dept Internal Med, Cologne, Germany
[6] F Hoffmann Roche Ltd, Pharma Dev Oncol, Basel, Switzerland
[7] Roche Prod Ltd, Pharma Dev Clin Sci, Welwyn Garden City, Herts, England
[8] Univ Hosp Schleswig Holstein, Campus Kiel, Kiel, Germany
[9] Roche Innovat Ctr Basel, PS, Roche Pharmaceut Res & Early Dev pRED, Basel, Switzerland
[10] Univ Ulm, Dept Internal Med 3, Ulm, Germany
[11] Ctr Integrated Oncol Koln, Dept Internal Med 1, Bonn, Germany
[12] Univ Cologne, Cluster Excellence Cellular Stress Responses Agin, Cologne, Germany
来源：
LEUKEMIA | 2016年 / 30卷 / 08期
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; IN-VITRO; RITUXIMAB; ANTIBODY; GA101;
D O I：
10.1038/leu.2016.41
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1763 / 1766
页数：5
相关论文
共 14 条
  • [1] Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
    Alduaij, Waleed
    Ivanov, Andrei
    Honeychurch, Jamie
    Cheadle, Eleanor J.
    Potluri, Sandeep
    Lim, Sean H.
    Shimada, Kazuyuki
    Chan, Claude H. T.
    Tutt, Alison
    Beers, Stephen A.
    Glennie, Martin J.
    Cragg, Mark S.
    Illidge, Tim M.
    [J]. BLOOD, 2011, 117 (17) : 4519 - 4529
  • [2] [Anonymous], ASCO M ABSTR S
  • [3] Mechanism of Action of Type II, Glycoengineered, Anti-CD20 Monoclonal Antibody GA101 in B-Chronic Lymphocytic Leukemia Whole Blood Assays in Comparison with Rituximab and Alemtuzumab
    Bologna, Luca
    Gotti, Elisa
    Manganini, Massimiliano
    Rambaldi, Alessandro
    Intermesoli, Tamara
    Introna, Martino
    Golay, Josee
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 186 (06) : 3762 - 3769
  • [4] Safety and Efficacy Of Obinutuzumab (GA101) With Fludarabine/Cyclophosphamide (G-FC) Or Bendamustine (G-B) In The Initial Therapy Of Patients With Chronic Lymphocytic Leukemia (CLL): Results From The Phase 1b Galton Trial (GA04779g)
    Brown, Jennifer R.
    O'Brien, Susan
    Kingsley, C. Daniel
    Eradat, Herbert
    Pagel, John M.
    Lymp, James
    Hirata, Jamie
    Kipps, Thomas J.
    [J]. BLOOD, 2013, 122 (21)
  • [5] High levels of CD20 expression predict good prognosis in chronic lymphocytic leukemia
    Fang, Cheng
    Zhuang, Yun
    Wang, Li
    Fan, Lei
    Wu, Yu-Jie
    Zhang, Run
    Zou, Zhi-Jian
    Zhang, Li-Na
    Yang, Shu
    Xu, Wei
    Li, Jian-Yong
    [J]. CANCER SCIENCE, 2013, 104 (08) : 996 - 1001
  • [6] Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study
    Goede, V.
    Fischer, K.
    Engelke, A.
    Schlag, R.
    Lepretre, S.
    Montero, L. F. C.
    Montillo, M.
    Fegan, C.
    Asikanius, E.
    Humphrey, K.
    Fingerle-Rowson, G.
    Hallek, M.
    [J]. LEUKEMIA, 2015, 29 (07) : 1602 - 1604
  • [7] Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions
    Goede, Valentin
    Fischer, Kirsten
    Busch, Raymonde
    Engelke, Anja
    Eichhorst, Barbara
    Wendtner, Clemens M.
    Chagorova, Tatiana
    de la Serna, Javier
    Dilhuydy, Marie-Sarah
    Illmer, Thomas
    Opat, Stephen
    Owen, Carolyn J.
    Samoylova, Olga
    Kreuzer, Karl-Anton
    Stilgenbauer, Stephan
    Doehner, Hartmut
    Langerak, Anton W.
    Ritgen, Matthias
    Kneba, Michael
    Asikanius, Elina
    Humphrey, Kathryn
    Wenger, Michael
    Hallek, Michael
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (12) : 1101 - 1110
  • [8] Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    Hallek, M.
    Fischer, K.
    Fingerle-Rowson, G.
    Fink, A. M.
    Busch, R.
    Mayer, J.
    Hensel, M.
    Hopfinger, G.
    Hess, G.
    von Gruenhagen, U.
    Bergmann, M.
    Catalano, J.
    Zinzani, P. L.
    Caligaris-Cappio, F.
    Seymour, J. F.
    Berrebi, A.
    Jaeger, U.
    Cazin, B.
    Trneny, M.
    Westermann, A.
    Wendtner, C. M.
    Eichhorst, B. F.
    Staib, P.
    Buehler, A.
    Winkler, D.
    Zenz, T.
    Boettcher, S.
    Ritgen, M.
    Mendila, M.
    Kneba, M.
    Doehner, H.
    Stilgenbauer, S.
    [J]. LANCET, 2010, 376 (9747) : 1164 - 1174
  • [9] Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models
    Herter, Sylvia
    Herting, Frank
    Mundigl, Olaf
    Waldhauer, Inja
    Weinzierl, Tina
    Fauti, Tanja
    Muth, Gunter
    Ziegler-Landesberger, Doris
    Van Puijenbroek, Erwin
    Lang, Sabine
    Minh Ngoc Duong
    Reslan, Lina
    Gerdes, Christian A.
    Friess, Thomas
    Baer, Ute
    Burtscher, Helmut
    Weidner, Michael
    Dumontet, Charles
    Umana, Pablo
    Niederfellner, Gerhard
    Bacac, Marina
    Klein, Christian
    [J]. MOLECULAR CANCER THERAPEUTICS, 2013, 12 (10) : 2031 - 2042
  • [10] Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
    Moessner, Ekkehard
    Bruenker, Peter
    Moser, Samuel
    Puentener, Ursula
    Schmidt, Carla
    Herter, Sylvia
    Grau, Roger
    Gerdes, Christian
    Nopora, Adam
    van Puijenbroek, Erwin
    Ferrara, Claudia
    Sondermann, Peter
    Jaeger, Christiane
    Strein, Pamela
    Fertig, Georg
    Friess, Thomas
    Schuell, Christine
    Bauer, Sabine
    Dal Porto, Joseph
    Del Nagro, Christopher
    Dabbagh, Karim
    Dyer, Martin J. S.
    Poppema, Sibrand
    Klein, Christian
    Umana, Pablo
    [J]. BLOOD, 2010, 115 (22) : 4393 - 4402
12