Tolerogenic pDCs: spotlight on Foxo3

被引:8
作者
Bronte, Vincenzo [1 ,2 ]
机构
[1] Univ Verona, Verona Univ Hosp, I-37134 Verona, Italy
[2] Univ Verona, Dept Pathol, Immunol Sect, I-37134 Verona, Italy
关键词
REGULATORY T-CELLS; DENDRITIC CELLS; INDOLEAMINE 2,3-DIOXYGENASE; METABOLISM; NITRATION; RESPONSES; IDO;
D O I
10.1172/JCI57190
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cancer creates a peculiar inflammatory environment enriched for transcription factors with a negative influence on adaptive immunity. In this issue of the JCI, Watkins and colleagues identify Foxo3 as a master regulator of the tolerogenic program in tumor-associated, plasmacytoid DCs (pDCs). Foxo3 enables pDCs to induce tolerance in tumor antigen-specific CD8(+) T cells, turning them into regulatory lymphocytes capable of inhibiting nearby CD8(+) T lymphocytes. Provision of tumor-specific CD4(+) T helper cells interrupts this circuit by inhibiting Foxo3 expression and fully licensing the antigen-presenting ability of pDCs. These data identify a new target for therapeutic intervention and provide insight into the transcription factor interplay in myeloid cells recruited to the cancer microenvironment.
引用
收藏
页码:1247 / 1250
页数:4
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