Gut Microbiota-Targeted Nutritional Interventions Improving Child Growth in Low- and Middle-Income Countries: A Systematic Review

被引:12
作者
Heuven, Lise Aj [1 ]
Pyle, Simone [2 ]
Greyling, Arno [2 ]
Melse-Boonstra, Alida [1 ]
Eilander, Ans [2 ]
机构
[1] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands
[2] Unilever Foods Innovat Ctr, Wageningen, Netherlands
关键词
child; growth; LMICs; nutrition; prebiotics; probiotics; synbiotics; INTERNATIONAL SCIENTIFIC ASSOCIATION; RANDOMIZED CONTROLLED-TRIAL; SEVERE ACUTE MALNUTRITION; DOUBLE-BLIND; CONSENSUS STATEMENT; PRESCHOOL-CHILDREN; PROBIOTICS; PREBIOTICS; DIARRHEA; WEIGHT;
D O I
10.1093/cdn/nzab124
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The objective of this systematic literature review was to evaluate the efficacy of probiotic, prebiotic, and synbiotic interventions compared with control on improving growth outcomes of children living in low- and middle-income countries (LMICs). Probiotics had a beneficial effect on >= 1 of the growth outcomes in 5 out of the 11 included studies. Of these, 3 studies were conducted in undernourished children, 1 in healthy children, and 1 in children without a described health status. No effect of prebiotics on growth outcomes was seen in the 4 included studies. Synbiotics had a beneficial effect on growth outcomes in 3 out of 4 studies. Although a limited number of studies with high heterogeneity indicate that probiotics and synbiotics may have the potential to improve the growth of both undernourished and healthy children living in LMICs, more research is needed to confirm the observed effects.
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页数:14
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