Synthesis and Characterization of some Novel Quinoxaline-2, 3-Dione Derivatives: A Preliminary Investigation on their Activity Against a Human Epithelial Carcinoma Cell Line

被引：8

作者：

Jubie, Selvaraj ^{[1
]}

Gayathri, Rajamanickam ^{[1
]}

Srividya, Ammayappan Rajam ^{[2
]}

Kalirajan, Rajagopal ^{[1
]}

Prabitha, Prabakaran ^{[1
]}

Sankar, Sundaram ^{[1
]}

Elango, Kannan ^{[1
]}

机构：

[1] Off Campus JSS Univ, JSS Coll Pharm, Dept Pharmaceut Chem, Mysore, Karnataka, India

[2] Off Campus JSS Univ, JSS Coll Pharm, Dept Pharmaceut Biotechnol, Mysore, Karnataka, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 04期

关键词：

Benzimidazole; Cytotoxicity; Quinoxaline-2,3-dione; SRB method; Electrophilic substitution; Human epithelial carcinoma cell line;

D O I：

10.2174/157018011794839385

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using H-1 NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity.

引用

页码：317 / 320

页数：4