Improving Therapeutic Vaccination against Hepatitis B-Insights from Preclinical Models of Immune Therapy against Persistent Hepatitis B Virus Infection

被引：6

作者：

Knolle, Percy A. ^{[1
,2
]}

Huang, Li-Rung ^{[3
]}

Kosinska, Anna ^{[4
]}

Wohlleber, Dirk ^{[1
]}

Protzer, Ulrike ^{[2
,4
]}

机构：

[1] Tech Univ Munich, Inst Mol Immunol & Expt Oncol, Sch Med, D-81675 Munich, Germany

[2] German Ctr Infect Res DZIF, Munich Site, D-81675 Munich, Germany

[3] Natl Hlth Res Inst, Inst Mol & Gen Med, Miaoli 350, Taiwan

[4] Tech Univ Munich, Inst Virol, Sch Med, D-81675 Munich, Germany

来源：

VACCINES | 2021年 / 9卷 / 11期

关键词：

hepatitis B virus (HBV); vaccination; therapeutic vaccination; T-CELL-ACTIVATION; EXHAUSTED PHENOTYPE; ENDOTHELIAL-CELLS; BOOST VACCINATION; VIRAL CLEARANCE; INNATE IMMUNITY; LIVER; ANTIGEN; TOLERANCE; EXPRESSION;

D O I：

10.3390/vaccines9111333

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic hepatitis B affects more than 250 million individuals worldwide, putting them at risk of developing liver cirrhosis and liver cancer. While antiviral immune responses are key to eliminating hepatitis B virus (HBV) infections, insufficient antiviral immunity characterized by failure to eliminate HBV-infected hepatocytes is associated with chronic hepatitis B. Prophylactic vaccination against hepatitis B successfully established protective immunity against infection with the hepatitis B virus and has been instrumental in controlling hepatitis B. However, prophylactic vaccination schemes have not been successful in mounting protective immunity to eliminate HBV infections in patients with chronic hepatitis B. Here, we discuss the current knowledge on the development and efficacy of therapeutic vaccination strategies against chronic hepatitis B with particular emphasis on the pathogenetic understanding of dysfunctional anti-viral immunity. We explore the development of additional immune stimulation measures within tissues, in particular activation of immunogenic myeloid cell populations, and their use for combination with therapeutic vaccination strategies to improve the efficacy of therapeutic vaccination against chronic hepatitis B.

引用

页数：14

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