Soluble HLA-G molecules are released as HLA-G5 and not as soluble HLA-G1 isoforms in CSF of patients with relapsing-remitting Multiple Sclerosis

被引：30

作者：

Fainardi, Enrico ^{[1
,2
]}

Rizzo, Roberta ^{[3
]}

Melchiorri, Loredana ^{[3
]}

Stignani, Marina ^{[3
]}

Castellazzi, Massimiliano ^{[1
]}

Caniatti, Maria Luisa ^{[1
]}

Baldi, Eleonora ^{[1
]}

Tola, Maria Rosaria ^{[1
]}

Granieri, Enrico ^{[1
]}

Baricordi, Avio Roberto ^{[3
,4
]}

机构：

[1] Univ Ferrara, Neurol Sect, Multiple Sclerosis Ctr, I-44100 Ferrara, Italy

[2] Azienda Osped Univ, Dept Neurosci, Neuroradiol Sect, I-44100 Ferrara, Italy

[3] Univ Ferrara, Dept Expt & Diagnost Med, Med Genet Sect, I-44100 Ferrara, Italy

[4] Univ Ferrara, Dept Expt & Diagnost Med, Ctr Biotechnol, I-44100 Ferrara, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

sHLA-G1; HLA-G5; cerebrospinal fluid; Multiple Sclerosis;

D O I：

10.1016/j.jneuroim.2007.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cerebrospinal fluid (CSF) levels of sHLA-G (sHLA-G1/HLA-G5) molecules and their soluble isoforms HLA-G5 and sHLA-G1 were measured by ELISA procedures in 68 relapsing-remitting Multiple Sclerosis (RR MS) patients, in 67 patients with other inflammatory neurological disorders (OIND) and in 70 subjects with non-inflammatory neurological disorders (NIND). CSF concentrations of sHLA-G1/HLA-G5 and HLA-G5 were higher in RR MS than in OIND and NIND, and in Magnetic Resonance Imaging (MRI) inactive as compared to MRI active RR MS. Our results indicate that the potential implication of sHLA-G proteins in the resolution of MS intrathecal inflammatory response is probably due to HLA-G5 isoform. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：219 / 225

页数：7

共 29 条

[1] HLA-G: a shield against inflammatory aggression [J].

Carosella, ED ;

Moreau, P ;

Aractingi, S ;

Rouas-Freiss, N .

TRENDS IN IMMUNOLOGY, 2001, 22 (10) :553-555

[2] Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NKCD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation [J].

Contini, P ;

Ghio, M ;

Poggi, A ;

Filaci, G ;

Indiveri, F ;

Ferrone, S ;

Puppo, F .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) :125-134

[3] Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis [J].

Fainardi, E ;

Rizzo, R ;

Melchiorri, L ;

Castellazzi, M ;

Paolino, E ;

Tola, MR ;

Granieri, E ;

Baricordi, OR .

MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (01) :2-12

[4] Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing-remitting multiple sclerosis: relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings [J].

Fainardi, E ;

Rizzo, R ;

Melchiorri, L ;

Vaghi, L ;

Castellazzi, M ;

Marzola, A ;

Govoni, V ;

Paolino, E ;

Tola, MR ;

Granieri, E ;

Baricordi, OR .

JOURNAL OF NEUROIMMUNOLOGY, 2003, 142 (1-2) :149-158

[5] HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation [J].

Feger, Ute ;

Tolosa, Eva ;

Huang, Yu-Hwa ;

Waschbisch, Anne ;

Biedermann, Tilo ;

Melms, Arthur ;

Wiendl, Heinz .

BLOOD, 2007, 110 (02) :568-577

[6] Soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8 [J].

Fournel, S ;

Aguerre-Girr, M ;

Huc, X ;

Lenfant, F ;

Alam, A ;

Toubert, A ;

Bensussan, A ;

Le Bouteiller, P .

JOURNAL OF IMMUNOLOGY, 2000, 164 (12) :6100-6104

[7] Medical progress: Multiple sclerosis - The plaque and its pathogenesis [J].

Frohman, EM ;

Racke, MK ;

Raine, CS .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (09) :942-955

[8]

Fuzzi B, 2002, EUR J IMMUNOL, V32, P311, DOI 10.1002/1521-4141(200202)32:2<311::AID-IMMU311>3.3.CO

[9]

2-#

[10] Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice [J].

Horuzsko, A ;

Lenfant, F ;

Munn, DH ;

Mellor, AL .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (03) :385-394

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