Stereoselective domino conjugate addition of Grignard reagents to lactones followed by reaction with activated alkenes catalyzed by ferrocenyl carbene ligands

被引：11
|
作者：
Soradova, Zuzana [1 ]
Mazikova, Jana [1 ]
Meciarova, Maria [1 ]
Sebesta, Radovan [1 ]
机构：
[1] Comenius Univ, Fac Nat Sci, Dept Organ Chem, SK-84215 Bratislava, Slovakia
来源：
TETRAHEDRON-ASYMMETRY | 2015年 / 26卷 / 5-6期
关键词：
QUATERNARY STEREOGENIC CENTERS; N-HETEROCYCLIC CARBENE; ALKOXY-NHC LIGANDS; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; TANDEM; COMPLEXES; DESIGN; ENONES; ARYL;
D O I：
10.1016/j.tetasy.2015.01.015
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ferrocenyl phosphane-carbene ligands catalyze domino reactions composed of conjugate addition of Grignard reagents to alpha,beta-unsaturated lactone followed by enolate trapping with activated alkenes. The corresponding alpha,beta-disubstituted lactones were obtained in medium yields, but with high diastereomeric and enantiomeric purities up to 98:2 er. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：271 / 275
页数：5
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