Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity

被引：30

作者：

Pujantell, Maria ^{[1
]}

Altfeld, Marcus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Immunol, Hamburg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

sex-differences; type I IFN; antiviral immunity; inflammation; antigen-presenting cells (APC); PLASMACYTOID DENDRITIC CELLS; MESSENGER-RNA TRANSLATION; ESTROGEN-RECEPTOR-ALPHA; CD8; T-CELLS; X-CHROMOSOME; DISTINCT REQUIREMENTS; MEDIATED RESPONSE; GENE-EXPRESSION; MENSTRUAL-CYCLE; INTERFERON;

D O I：

10.3389/fimmu.2022.986840

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological homeostasis to avoid excessive inflammation and damage to the host. Sex differences in the manifestation and progression of immune-mediated disease point to sex-specific factors modulating antiviral immunity. The exact mechanisms regulating these immunological differences between females and males are still insufficiently understood. Females are known to display stronger Type I IFN responses and are less susceptible to viral infections compared to males, indicating that Type I IFN responses might contribute to the sexual dimorphisms observed in antiviral responses. Here, we review the impact of sex hormones and X chromosome-encoded genes on differences in Type I IFN responses between females and males; and discuss the consequences of sex differences in Type I IFN responses for the regulation of antiviral immune responses.

引用

页数：10