Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity

被引:30
作者
Pujantell, Maria [1 ]
Altfeld, Marcus [1 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Inst Immunol, Hamburg, Germany
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词
sex-differences; type I IFN; antiviral immunity; inflammation; antigen-presenting cells (APC); PLASMACYTOID DENDRITIC CELLS; MESSENGER-RNA TRANSLATION; ESTROGEN-RECEPTOR-ALPHA; CD8; T-CELLS; X-CHROMOSOME; DISTINCT REQUIREMENTS; MEDIATED RESPONSE; GENE-EXPRESSION; MENSTRUAL-CYCLE; INTERFERON;
D O I
10.3389/fimmu.2022.986840
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological homeostasis to avoid excessive inflammation and damage to the host. Sex differences in the manifestation and progression of immune-mediated disease point to sex-specific factors modulating antiviral immunity. The exact mechanisms regulating these immunological differences between females and males are still insufficiently understood. Females are known to display stronger Type I IFN responses and are less susceptible to viral infections compared to males, indicating that Type I IFN responses might contribute to the sexual dimorphisms observed in antiviral responses. Here, we review the impact of sex hormones and X chromosome-encoded genes on differences in Type I IFN responses between females and males; and discuss the consequences of sex differences in Type I IFN responses for the regulation of antiviral immune responses.
引用
收藏
页数:10
相关论文
共 50 条
[31]   Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1 [J].
Zhan, Zhenzhen ;
Cao, Hao ;
Xie, Xuefeng ;
Yang, Linshan ;
Zhang, Peng ;
Chen, Yihan ;
Fan, Huimin ;
Liu, Zhongmin ;
Liu, Xingguang .
JOURNAL OF IMMUNOLOGY, 2015, 195 (08) :3849-3857
[32]   Sex differences in complex regional pain syndrome type I (CRPS-I) in mice [J].
Tang, Chaoliang ;
Li, Juan ;
Tai, Wai Lydia ;
Yao, Weifeng ;
Zhao, Bo ;
Hong, Junmou ;
Shi, Si ;
Wang, Song ;
Xia, Zhongyuan .
JOURNAL OF PAIN RESEARCH, 2017, 10 :1811-1819
[33]   Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1 [J].
Wang, Pin ;
Hou, Jin ;
Lin, Li ;
Wang, Chunmei ;
Liu, Xingguang ;
Li, Dong ;
Ma, Feng ;
Wang, Zhugang ;
Cao, Xuetao .
JOURNAL OF IMMUNOLOGY, 2010, 185 (10) :6226-6233
[34]   A RIG-I 2CARD-MAVS200 Chimeric Protein Reconstitutes IFN-β Induction and Antiviral Response in Models Deficient in Type I IFN Response [J].
Nistal-Villan, Estanislao ;
Rodriguez-Garcia, Estefania ;
Di Scala, Marianna ;
Ferrero-Laborda, Roberto ;
Olaguee, Cristina ;
Vales, Africa ;
Carte-Abad, Beatriz ;
Crespo, Irene ;
Garcia-Sastre, Adolfo ;
Prieto, Jesus ;
Larrea, Esther ;
Gonzalez-Aseguinolaza, Gloria .
JOURNAL OF INNATE IMMUNITY, 2015, 7 (05) :466-481
[35]   Type I IFN-mediated regulation of IL-1 production in inflammatory disorders [J].
Ludigs, Kristina ;
Parfenov, Valeriy ;
Du Pasquier, Renaud A. ;
Guarda, Greta .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (20) :3395-3418
[36]   Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression [J].
Du, Li ;
Liu, Wei ;
Rosen, Steven T. ;
Chen, Yuan .
JOURNAL OF MOLECULAR BIOLOGY, 2023, 435 (05)
[37]   A novel mechanism for regulation of the type I IFN response by herpesvirus deconjugases [J].
Gupta, Soham ;
Yla-Anttila, Paivi ;
Masucci, Maria G. .
MICROBIAL CELL, 2018, 5 (05) :259-261
[38]   IRF11 regulates positively type I IFN transcription and antiviral response in mandarin fish, Siniperca chuatsi [J].
Li, Li ;
Chen, Shan Nan ;
Nie, P. .
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 114
[39]   Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses [J].
Kaur, Surinder ;
Sassano, Antonella ;
Majchrzak-Kita, Beata ;
Baker, Darren P. ;
Su, Bing ;
Fish, Eleanor N. ;
Platanias, Leonidas C. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (20) :7723-7728
[40]   A Tug of War: DNA-Sensing Antiviral Innate Immunity and Herpes Simplex Virus Type I Infection [J].
Lin, Yingying ;
Zheng, Chunfu .
FRONTIERS IN MICROBIOLOGY, 2019, 10