A combination of selenium and polysaccharides: Promising therapeutic potential

被引：135
作者：
Li, Jing [1 ]
Shen, Bingxiang [1 ]
Nie, Songliu [1 ]
Duan, Zihao [1 ]
Chen, Kaoshan [2 ,3 ,4 ]
机构：
[1] Anhui Med Univ, Luan Affiliated Hosp, Dept Pharm, Luan 237000, Peoples R China
[2] Wannan Med Coll, Anhui Prov Key Lab Active Biol Macromol, Anhui Prov Engn Res Ctr Polysaccharide Drugs, Drug Res & Dev Ctr,Sch Pharm, 22 West Wenchang Rd, Wuhu 241002, Peoples R China
[3] Shandong Univ, Sch Life Sci, 27 South Shanda Rd, Jinan 250100, Shandong, Peoples R China
[4] Shandong Univ, Natl Glycoengn Res Ctr, 27 South Shanda Rd, Jinan 250100, Shandong, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2019年 / 206卷
关键词：
Selenium; Polysaccharides; Combination; Bioactivities; Therapeutic potential; ZIYANG GREEN TEA; ANTIOXIDANT ACTIVITY; ELEMENTAL SELENIUM; IMMUNOMODULATORY ACTIVITY; SELENYLATION MODIFICATION; ANTIDIABETIC ACTIVITY; NANO-SE; SURFACE DECORATION; ANTI-INFLAMMATION; PROTEIN COMPLEXES;
D O I：
10.1016/j.carbpol.2018.10.088
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Currently, selenium and polysaccharide combinations can be identified as three forms: natural selenium polysaccharides, synthetic selenium polysaccharides and selenium nanoparticles decorated with polysaccharides. Previous studies have indicated that these three combinations generally show better bioactivities, including immunomodulation, anti-tumour, antioxidation and glucose regulation, than those of either selenium or polysaccharides alone. Although they have not yet been developed as new drugs for clinical trials, results from previous studies have already shown their therapeutic potential for the future. In this article, we summarize our current state of understanding of the sources, preparation methods, physicochemical characteristics and bioactivities of these combinations for the discovery of novel therapeutic drugs and adjuvants.
引用
收藏
页码：163 / 173
页数：11
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