Trends in analytical atomic and molecular mass spectrometry in biology and the life sciences

被引：26
作者：
Careri, Maria [1 ]
Mangia, Alessandro [1 ]
机构：
[1] Univ Parma, Dipartimento Chim Gen & Inorgan, I-43100 Parma, Italy
来源：
ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2011年 / 399卷 / 08期
关键词：
Mass spectrometry imaging; Ion mobility mass spectrometry; Laser ablation; ICP-MS; Matrix-free laser desorption/ionization MS; Microfluidics; Miniature mass spectrometers; Multiplexed analysis; Biosciences; ABLATION ELECTROSPRAY-IONIZATION; DIRECT TISSUE-ANALYSIS; LA-ICP-MS; ATMOSPHERIC-PRESSURE; AMBIENT CONDITIONS; MICROFABRICATED DEVICE; MOBILITY SPECTROMETER; SILVER NANOPARTICLES; MATRIX DEPOSITION; MALDI-MS;
D O I：
10.1007/s00216-010-4585-8
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Trends in analytical atomic and molecular mass spectrometry (MS) are reviewed here with an emphasis on problems related to biology and the life sciences. The move towards novel desorption/ionization techniques including matrix-free laser desorption-ionization MS and recent technological developments in MS imaging of elements, small molecules, and proteins are discussed. Recent developments in the interfacing of microfluidics with MS are also reviewed. Metabolic profiling, evaluation of biomarkers, pharmaceutical metabolite identification, and many related topics are addressed.
引用
收藏
页码：2585 / 2595
页数：11
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