Hedgehog pathway aberrations and gastric cancer; evaluation of prognostic impact and exploration of therapeutic potentials

被引：22
作者：
Abdel-Rahman, Omar [1 ]
机构：
[1] Ain Shams Univ, Fac Med, Dept Clin Oncol, Cairo, Egypt
来源：
TUMOR BIOLOGY | 2015年 / 36卷 / 03期
关键词：
Gastric cancer; Hedghog; Vismodegib; SONIC-HEDGEHOG; SIGNALING PATHWAY; PHASE-II; ACTIVATION; GROWTH; CELL; EXPRESSION; VISMODEGIB; CONTRIBUTES; PLACEBO;
D O I：
10.1007/s13277-015-3216-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer is an important cause for mortality and morbidity worldwide; it lies in the fourt rank as a cause of cancer-related death in males and in the fifth rank of cancer-related death in women. The prognosis of advanced/metastatic gastric cancer cases looks poor with the majority of available therapeutics. Thus, novel therapeutic strategies in this setting have been considered a priority for leading cooperative oncology groups. Hedgehog(Hh) pathway aberrations have sparked particular interest as prognostic markers with data from multiple studies showing consistent evidence of a poor prognostic value of Gli over expression in gastric cancer while on the other hand the prognostic significance of Hh protein over expression (particularly SHH) was not consistent among different studies. This review article revises the prognostic and potential therapeutic opportunities in the targeting of hedgehog pathway in gastric cancer.
引用
收藏
页码：1367 / 1374
页数：8
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