Epstein-Barr virus as a marker of biological aggressiveness in breast cancer

被引：63
作者：
Mazouni, C. [1 ,2 ]
Fina, F. [1 ]
Romain, S. [1 ]
Ouafik, L. [3 ]
Bonnier, P. [4 ]
Brandone, J-M [5 ]
Martin, P-M [1 ]
机构：
[1] Fac Med Nord, Lab Transfert Oncol Biol, Assistance Publ Hop Marseille, Marseille, France
[2] Inst Gustave Roussy, Dept Chirurg Gen, F-94805 Villejuif, France
[3] Ctr Rech Oncol Biol & Oncopharmacol, UMR 911, CRO2, F-13344 Marseille, France
[4] Clin Beauregard, Dept Oncol Chirurg Mammaire & Gynecol, Marseille, France
[5] Clin Bouchard, Dept Chirurg Gynecol, Marseille, France
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 02期
关键词：
breast cancer; Epstein-Barr virus; HER2; real-time quantitative PCR; thymidine kinase; LYMPHOEPITHELIOMA-LIKE CARCINOMA; REAL-TIME PCR; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; MEDULLARY CARCINOMA; LYMPHOID STROMA; EBV GENOME; DNA; INFECTION; ASSOCIATION;
D O I：
10.1038/sj.bjc.6606048
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PURPOSE: Although a potential role of the Epstein-Barr virus (EBV) in the pathogenesis of breast cancer (BC) has been underlined, results remain conflicting. Particularly, the impact of EBV infection on biological markers of BC has received little investigation. METHODS: In this study, we established the frequency of EBV-infected BC using real-time quantitative PCR (RT-PCR) in 196 BC specimens. Biological and pathological characteristics according to EBV status were evaluated. RESULTS: EBV DNA was present in 65 of the 196 (33.2%) cases studied. EBV-positive BCs tended to be tumours with a more aggressive phenotype, more frequently oestrogen receptor negative (P = 0.05) and with high histological grade (P = 0.01). Overexpression of thymidine kinase activity was higher in EBV-infected BC (P = 0.007). The presence of EBV was weakly associated with HER2 gene amplification (P = 0.08). CONCLUSION: Our study provides evidence for EBV-associated BC undergoing distinct carcinogenic processes, with more aggressive features. British Journal of Cancer (2011) 104, 332-337. doi: 10.1038/sj.bjc.6606048 www.bjcancer.com Published online 21 December 2010 (C) 2011 Cancer Research UK
引用
收藏
页码：332 / 337
页数：6
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