Adiponectin reduces carotid atherosclerotic plaque formation in ApoE-/- mice: Roles of oxidative and nitrosative stress and inducible nitric oxide synthase

被引：31

作者：

Cai, Xiaojun ^{[1
,2
,3
]}

Li, Xuan ^{[1
,2
,4
]}

Li, Li ^{[1
,2
,3
]}

Huang, Xiao-Zhen ^{[1
,2
,5
]}

Liu, Yu-Sheng ^{[1
,2
,6
]}

Chen, Liang ^{[1
,2
]}

Zhang, Ke ^{[1
,2
]}

Wang, Lin ^{[1
,2
]}

Li, Xiaonan ^{[1
,2
]}

Song, Jiantao ^{[1
,2
]}

Li, Shuzhen ^{[3
]}

Zhang, Yun ^{[1
,2
]}

Zhang, Mei ^{[1
,2
]}

机构：

[1] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Qilu Hosp, Chinese Minist Publ Hlth, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Dept Cardiol, Jinan Cent Hosp, Jinan 250014, Shandong, Peoples R China

[4] Weifang Tradit Chinese Med Hosp, Dept Cardiol, Weifang 261041, Shandong, Peoples R China

[5] Jinan Huaiyin Hosp, Dept Cardiol, Jinan 250021, Shandong, Peoples R China

[6] Shandong Univ, Hosp 2, Dept Cardiol, Jinan 250033, Shandong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2015年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

adiponectin; atherosclerosis; oxidative stress; nitrite/nitrate; inducible nitric oxide synthase; IMPROVES ENDOTHELIAL FUNCTION; ADIPOSE-SPECIFIC PROTEIN; TYPE-2 DIABETIC MICE; OXIDATIVE/NITRATIVE STRESS; HYPERLIPIDEMIC RATS; ADHESION MOLECULES; INSULIN-RESISTANCE; METABOLIC SYNDROME; SIGNALING PATHWAY; CORONARY-ARTERY;

D O I：

10.3892/mmr.2014.2947

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adiponectin (APN) is an important anti-atherogenic adipocytokine. The aim of the present study was to investigate the role of adiponectin in atherosclerotic plaque formation and clarify its mechanisms. An atherosclerosis model was induced by in vivo perivascular constrictive silica collar placement on the left common carotid arteries in male apolipoprotein E-deficient (ApoE(-/-)) mice. All of the mice were fed a high-fat diet, and divided into phosphate-buffered saline, adenovirus (Ad)-beta-galactosidase and Ad-APN treatment groups. Compared with treatment of Ad-beta-gal or PBS, Ad-APN treatment markedly reduced inducible nitric oxide synthase (iNOS) protein expression, decreased in nitric oxide/superoxide production, blocked peroxynitrite formation and reversed the progression of atherosclerotic lesions. Adiponectin may be a natural molecule that reduces atherosclerosis by inhibiting iNOS and consequently diminishing oxidative/nitrative stress.

引用

页码：1715 / 1721

页数：7

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