Effect of pyridoxine and insulin administration on brain glutamate dehydrogenase activity and blood glucose control in streptozotocin-induced diabetic rats

被引：12

作者：

Nair, AR ^{[1
]}

Biju, MP ^{[1
]}

Paulose, CS ^{[1
]}

机构：

[1] Cochin Univ Sci & Technol, Dept Biotechnol, Mol Neurobiol & Cell Biol Unit, Cochin 682022, Kerala, India

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1998年 / 1381卷 / 03期

关键词：

streptozotocin-diabetes; pyridoxine; insulin; glutamate dehydrogenase; blood glucose; brain;

D O I：

10.1016/S0304-4165(98)00054-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blood glucose level and kinetic parameters of glutamate dehydrogenase (GDH) were measured in the cerebellum, brain stem and cerebral cortex of control, insulin treated, pyridoxine treated, pyridoxine and insulin treated and untreated streptozotocin-diabetic rats. The combined administration of insulin and pyridoxine was found to be better in controlling the hyperglycaemia. Insulin with pyridoxine treatment brought back the increased maximal velocity of GDH during diabetes to control state. Also, there was an increase in Michaelis-Menten constant. These results suggest that pyridoxine and insulin together serve a better control for diabetes. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：351 / 354

页数：4

共 20 条

[1] INHIBITION OF GLUTAMIC DEHYDROGENASE BY PYRIDOXAL 5-PHOSPHATE
ANDERSON, BM
ANDERSON, CD
CHURCHIC.JE
[J]. BIOCHEMISTRY, 1966, 5 (09) : 2893 - &
[2] ATLANTE A, 1997, J NEUROCHEM, V68, P2043
[3] Berman F W, 1996, J Biochem Toxicol, V11, P111, DOI 10.1002/(SICI)1522-7146(1996)11:3<111::AID-JBT2>3.0.CO
[4] 2-N
[5] Biju MP, 1998, BIOCHEM MOL BIOL INT, V44, P1
[6] Budd SL, 1996, J NEUROCHEM, V67, P2282
[7] CELIA WT, 1984, ANNU REV BIOCHEM, V53, P749
[8] Modification of brain glutamate dehydrogenase isoproteins with pyridoxal 5'-phosphate
Cho, SW
Lee, JE
[J]. BIOCHIMIE, 1996, 78 (10) : 817 - 821
[9] DENNIS P, 1971, BIOCHEMISTRY-US, V10, P4538
[10] REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN
GLOWINSKI, J
IVERSEN, LL
[J]. JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) : 655 - +

← 1 2 →