TACE: a new target in epidermal growth factor receptor dependent tumors

被引：50

作者：

Kenny, Paraic A. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Div Life Sci, Berkeley, CA 94720 USA

来源：

DIFFERENTIATION | 2007年 / 75卷 / 09期

关键词：

breast cancer; TACE; EGFR; metalloproteinases; cancer therapy;

D O I：

10.1111/j.1432-0436.2007.00198.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Soluble proteins play vital roles in mediating intercellular communication. Many of these proteins are secreted as freely soluble molecules, but an important class of signaling proteins are first synthesized and presented at the cell surface as transmembrane precursor proteins. Unlike classically secreted proteins, many of these molecules are regulated at an additional level, requiring proteolytic cleavage for activity. This review focuses on a subset of these proteins, which are cleaved by tumor necrosis factor alpha-converting enzyme (TACE)/ADAM17, and on their role in cancer.

引用

页码：800 / 808

页数：9

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