Thymosin beta 4 induces hair growth via stem cell migration and differentiation

被引：50

作者：

Philp, Deborah ^{[1
]}

St-Surin, Sharleen ^{[1
]}

Cha, Hee-Jae ^{[1
]}

Moon, Hye-Sung ^{[1
]}

Kleinman, Hynda K. ^{[1
]}

Elkin, Michael ^{[1
]}

机构：

[1] NIDCR, Cell Biol Sect, NIH, Bethesda, MD 20892 USA

来源：

THYMOSINS IN HEALTH AND DISEASE: FIRST INTERNATIONAL SYMPOSIUM | 2007年 / 1112卷

关键词：

cell migration; hair follicle growth; angiogenesis; wound healing; stem cells; cell survival; inflammation; gene expression; laminin-5; proteases; zyxin; endothelial cells; thymosin beta 4; keratinocytes; MMPs; TIMPs;

D O I：

10.1196/annals.1415.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.

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收藏

页码：95 / 103

页数：9

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