Therapeutic Efficacy of Basic Fibroblast Growth Factor in Patients With Vocal Fold Atrophy

被引:12
作者
Okui, Ayako [1 ,2 ]
Konomi, Ujimoto [1 ]
Kanazawa, Takeharu [1 ]
Komazawa, Daigo [1 ]
Nakamura, Kazuhiro [1 ,3 ]
Matsushima, Koji [1 ,4 ]
Watanabe, Yusuke [1 ]
机构
[1] Int Univ Hlth & Welf, Tokyo Voice Ctr, Tokyo, Japan
[2] Int Univ Hlth & Welf, Grad Sch, Grad Sch Med, Tokyo, Japan
[3] Nihon Univ, Itabashi Hosp, Dept Otolaryngol Head & Neck Surg, Tokyo, Japan
[4] Toho Univ, Omori Med Ctr, Dept Otolaryngol Head & Neck Surg, Tokyo, Japan
关键词
Basic fibroblast growth factor; vocal fold atrophy; elderly patients; regenerative medicine; AGE-RELATED-CHANGES; HYALURONIC-ACID; INJECTION; REGENERATION; TRIAL; COLLAGEN;
D O I
10.1002/lary.28541
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives/Hypothesis In recent years, basic fibroblast growth factor (bFGF) injection has been used in the treatment of aging-related vocal fold atrophy. This injection not only improves closure by increasing the mass of the vocal fold but also improves its viscoelasticity. However, it has been reported that fibroblasts targeted by bFGF treatment decrease in number with age. The purpose of this study was to examine the effects of local injection of bFGF on age-related vocal atrophy as well as the influence of age on phonological outcomes. Study Design Retrospective chart review. Methods Fifty-three patients with age-related vocal fold atrophy underwent single injections of bFGF in their vocal folds. Phonological outcomes were evaluated 3 and 6 months after injection by acoustic and aerodynamic measurements. Results Voice Handicap Index (VHI), maximum phonation time (MPT), jitter, shimmer, and pitch range improved after injection, and the effects continued for 6 months. In those over 70 years of age, VHI and MPT showed improvement at 3 and 6 months after injection. In addition, the degree of improvement in VHI and MPT did not differ significantly between those older than 70 years and those younger than 70 years. Conclusions Regenerative treatments dependent on bFGF single injection was safe and effective for both early and late elderly patients suffering of vocal fold atrophy. Level of Evidence 2c Laryngoscope, 2020
引用
收藏
页码:2847 / 2852
页数:6
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