Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies

被引：27
作者：
Dai, Shiyu [1 ,2 ]
Deng, Fei [1 ,2 ,3 ]
Wang, Hualin [1 ,2 ,3 ]
Ning, Yunjia [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Peoples R China
[2] Chinese Acad Sci, Natl Virus Resource Ctr, Wuhan Inst Virol, Wuhan 430071, Peoples R China
[3] Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan 430071, Peoples R China
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Crimean-Congo hemorrhagic fever virus; bunyavirus; tick-borne virus; antiviral strategies; IN-VITRO; REPLICATION; RIBAVIRIN; IDENTIFICATION; FAVIPIRAVIR; CHLOROQUINE; INHIBITION; UBIQUITIN;
D O I：
10.3390/v13071195
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients or infected animals with viremia. Currently, climate change and globalization have increased the transmission risk of this biosafety level (BSL)-4 virus. The treatment options of CCHFV infection remain limited and there is no FDA-approved vaccine or specific antivirals, which urges the identification of potential therapeutic targets and the design of CCHF therapies with greater effort. In this article, we discuss the current progress and some future directions in the development of antiviral strategies against CCHFV.
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