A controlled clinical trial comparing potent progestins, LNG-IUS and dienogest, for the treatment of women with adenomyosis

被引:26
|
作者
Ota, Ikuko [1 ]
Taniguchi, Fuminori [2 ]
Ota, Yoshiaki [3 ]
Nagata, Hiroki [2 ]
Wada, Ikumi [2 ]
Nakaso, Takaya [2 ]
Ikebuchi, Ai [2 ]
Sato, Eri [2 ]
Azuma, Yukihiro [2 ]
Harada, Tasuku [2 ]
机构
[1] Kurashiki Heisei Hosp, Dept Gynecol, Kurashiki, Okayama, Japan
[2] Tottori Univ, Fac Med, Dept Obstet & Gynecol, 36-1 Nishicho, Yonago, Tottori 6838504, Japan
[3] Kawasaki Med Sch, Dept Gynecol Oncol, Kurashiki, Okayama, Japan
关键词
adenomyosis; dienogest; LNG-IUS; pelvic pain; uterine bleeding; PAINFUL SYMPTOMS;
D O I
10.1002/rmb2.12408
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Purpose To evaluate the efficacy of two progestins, levonorgestrel intrauterine system (LNG-IUS) and dienogest (DNG), for adenomyosis. Methods This study enrolled 157 women with adenomyosis, randomized to either LNG-IUS (n = 76) or DNG (n = 81) groups as a controlled clinical trial for 72 months. Participants were classified by three different localizations of adenomyosis: diffuse, focal, and extrinsic. VAS (Visual analog scale) score, days, and amount of uterine bleeding were assessed. Uterine volume or bone mineral density (BMD) were measured by three-dimensional ultrasonography or dual-energy X-ray absorptiometry. Results LNG-IUS and DNG comparably reduced pain scores in patients with adenomyosis. With regard to pain control, DNG offered greater efficacy than LNG-IUS in 3 months of treatment. In all types of adenomyosis, the days of bleeding after 12 months with DNG were significantly decreased compared to those with LNG-IUS. The decrease of whole uterine body was transient in any subtypes. A comparable decrease in BMD due to age-related changes in both groups was observed. Conclusions LNG-IUS and DNG could be useful for long-term management of adenomyosis. In terms of durations of uterine bleeding, DNG was superior to LNG-IUS for 6 years.
引用
收藏
页码:427 / 434
页数:8
相关论文
共 50 条
  • [31] RANDOMIZED, CONTROLLED CLINICAL-TRIAL COMPARING PHOTOCHEMOTHERAPY WITH DITHRANOL IN INITIAL TREATMENT OF CHRONIC PLAQUE PSORIASIS
    VELLABRIFFA, D
    MARKS, J
    GREAVES, MW
    ROGERS, S
    SHUSTER, S
    WARIN, AP
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1978, 3 (04) : 339 - 347
  • [32] Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome
    Tao, Deshuang
    Zhong, Tangwu
    Ma, Shuxia
    Li, Jialin
    Li, Xiaojie
    ANNALS OF GENERAL PSYCHIATRY, 2019, 18 (01)
  • [33] Comparing treatment fidelity between study arms of a randomized controlled clinical trial for stroke family caregivers
    McLennon, Susan M.
    Hancock, Rebecca D.
    Redelman, Kathleen
    Scarton, Lisa J.
    Riley, Elizabeth
    Sweeney, Bobbie
    Habermann, Barbara
    Jessup, Nenette M.
    Bakas, Tamilyn
    CLINICAL REHABILITATION, 2016, 30 (05) : 495 - 507
  • [34] A randomised controlled trial comparing TVTTM, PelvicolTM and autologous fascial slings for the treatment of stress urinary incontinence in women
    Guerrero, K. L.
    Emery, S. J.
    Wareham, K.
    Ismail, S.
    Watkins, A.
    Lucas, M. G.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2010, 117 (12) : 1493 - 1503
  • [35] A randomised, controlled trial comparing TVT, pelvicol and autologous fascial slings for the treatment of stress urinary incontinence in women
    Guerrero, K.
    Wareham, K.
    Ismail, S.
    Lucas, M. G.
    Emery, S. J.
    BJU INTERNATIONAL, 2008, 101 : 26 - 26
  • [36] Dynamic lumbopelvic stabilization for treatment of stress urinary incontinence in women: Controlled and randomized clinical trial
    Abreu, Nathalia de Souza
    Villas Boas, Bia de Castro
    Bastos Netto, Jose Murilo
    Figueiredo, Andre Avarese
    NEUROUROLOGY AND URODYNAMICS, 2017, 36 (08) : 2160 - 2168
  • [37] A CONTROLLED CLINICAL-TRIAL COMPARING PYRETHRIN AND MALATHION LOTIONS FOR TREATMENT OF PEDICULOSIS CAPITIS IN SCHOOL-CHILDREN
    CHOSIDOW, O
    CHASTANG, C
    BRUE, C
    BOUVET, E
    IZRI, M
    MONTENY, N
    BASTUJIGARIN, S
    ROUSSET, JJ
    REVUZ, J
    CLINICAL RESEARCH, 1993, 41 (02): : A417 - A417
  • [38] Comparing the effect of sucrose gel and metronidazole gel in treatment of clinical symptoms of bacterial vaginosis: a randomized controlled trial
    Khazaeian, Somayyeh
    Navidian, Ali
    Navabi-Rigi, Shahin-dokht
    Araban, Marzieh
    Mojab, Faraz
    Khazaeian, Safoura
    TRIALS, 2018, 19
  • [39] Comparing the effect of sucrose gel and metronidazole gel in treatment of clinical symptoms of bacterial vaginosis: a randomized controlled trial
    Somayyeh Khazaeian
    Ali Navidian
    Shahin-dokht Navabi-Rigi
    Marzieh Araban
    Faraz Mojab
    Safoura Khazaeian
    Trials, 19
  • [40] A CONTROLLED CLINICAL-TRIAL COMPARING PYRETHRIN AND MALATHION LOTIONS FOR TREATMENT OF PEDICULOSIS CAPITIS IN SCHOOL-CHILDREN
    CHOSIDOW, O
    CHASTANG, CI
    BRUE, C
    BOUVET, E
    IZRI, M
    MONTENY, N
    BASTUJIGARIN, S
    ROUSSET, JJ
    REVUZ, J
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 100 (04) : 519 - 519