Highly efficient asymmetric reduction of arylpropionic aldehydes by Horse Liver Alcohol Dehydrogenase through dynamic kinetic resolution

被引：50
|
作者：
Giacomini, Daria
Galletti, Paola
Quintavalla, Arianna
Gucciardo, Gabriele
Paradisi, Francesca
机构：
[1] Univ Bologna, Dept Chem G Ciamician, Ahna Mater Mater Studiorum, I-40126 Bologna, Italy
[2] UCD, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 39期
关键词：
D O I：
10.1039/b712290j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The enantioselective synthesis of (2S)-2-phenylpropanol and ( 2S)-2-(4-iso-butylphenyl) propanol ((S)-Ibuprofenol) has been achieved by means of Horse Liver Alcohol Dehydrogenase (HLADH) in buffered aqueous solution or buffered organic solvent mixtures; under the reaction conditions, a dynamic kinetic resolution (DKR) process was realized with good reaction yields and enantiomeric ratios.
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页码：4038 / 4040
页数：3
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