Chondroblastic Osteosarcoma Arising in a Bone Infarct in a Patient with a Prior History of Hodgkin Lymphoma

Osteosarcoma is the most common primary bone cancer affecting adolescent and young adults. The majority of osteosarcomas occur sporadically, although increasing age is associated with a higher risk of secondary osteosarcoma. Common causes of secondary osteosarcoma include pre-existing Paget's disease and prior irradiation. Bone infarct-associated sarcoma (IAS) is a rare subset of secondary sarcoma with few reports to date. We present the case of a 28-year-old male who presented with IAS potentially related to previous steroid exposure from treated Hodgkin disease in childhood. He is currently undergoing neoadjuvant chemotherapy with consideration of a limb-sparing surgery after two cycles.