A new neuroprotective bakkenolide from the rhizome of Peatasites tatewakianus

被引：16

作者：

Sun, Zhen-Liang ^{[1
]}

Gao, Gang-Long ^{[1
]}

Luo, Jian-Ying ^{[1
]}

Zhang, Xue-Li ^{[1
]}

Zhang, Ming ^{[1
]}

Feng, Jing ^{[1
]}

机构：

[1] Shanghai 6 Peoples Hosp, Branch Hosp Fengxian, Shanghai 201400, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 03期

关键词：

Peatasites tatewakianus; Neuroprotection; Bakkenolide-VI; PETASITES-JAPONICUS MAXIM; SESQUITERPENES; DERIVATIVES; TRICHOLOBUS; FORMOSANUS; NEURONS; ROOT;

D O I：

10.1016/j.fitote.2010.11.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Constituents of the fruits of Peatasites tatewakianus were investigated. A new compound, namely bakkenolide-VI (1), was isolated. The structures was elucidated on the basis of ID, 2D NMR, TOF-MS and ESI-MS techniques, and physicochemical properties. The neuroprotective activity of the new compound was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. (c) 2010 Elsevier B.V. All rights reserved.

引用

页码：401 / 404

页数：4

共 18 条

[1]

ABE N, 1968, TETRAHEDRON LETT, V9, P1993

[2] Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten [J].

Dok-Go, H ;

Lee, HH ;

Kim, HJ ;

Lee, EH ;

Lee, JY ;

Song, YS ;

Lee, YH ;

Jin, CB ;

Lee, YS ;

Cho, J .

BRAIN RESEARCH, 2003, 965 (1-2) :130-136

[3]

JIANG Y, 1979, FLORA REPUBLICAE POP, V71, P94

[4] Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants [J].

Jung, YS ;

Kang, TS ;

Yoon, JH ;

Joe, BY ;

Lim, HJ ;

Seong, CM ;

Park, WK ;

Kong, JY ;

Cho, J ;

Park, NS .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (18) :2599-2602

[5] Neuroprotection of nicotiflorin in permanent focal cerebral ischemia and in neuronal cultures [J].

Li, Runping ;

Guo, Meili ;

Zhang, Ge ;

Xu, Xiongfei ;

Li, Quan .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (09) :1868-1872

[6] Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite [J].

Muyderman, H ;

Nilsson, M ;

Sims, NR .

JOURNAL OF NEUROSCIENCE, 2004, 24 (37) :8019-8028

[7] STRUCTURAL ELUCIDATION OF SESQUITERPENE LACTONES FROM PETASITES-JAPONICUS MAXIM [J].

NAYA, K ;

HAYASHI, M ;

TAKAGI, I ;

NAKAMURA, S ;

KOBAYASH.M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1972, 45 (12) :3673-3685

[8] PETASITES COMPONENTS .3. STRUCTURE OF THE SESQUITERPENES OF PETASITES-HYBRIDUS (L) GM ET SCH - PETASOL AND ISOPETASOL DERIVATIVES [J].

NEUENSCHWANDER, M ;

NEUENSCHWANDER, A ;

STEINEGGER, E ;

ENGEL, P .

HELVETICA CHIMICA ACTA, 1979, 62 (02) :609-626

[9] Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support [J].

Ohgoh, M ;

Kimura, M ;

Ogura, H ;

Katayama, K ;

Nishizawa, Y .

EXPERIMENTAL NEUROLOGY, 1998, 149 (01) :51-63

[10] Eremophilane-type sesquiterpenes from fresh rhizomes of Petasites japonicus [J].

Tori, M ;

Kawahara, M ;

Sono, M .

PHYTOCHEMISTRY, 1998, 47 (03) :401-409

← 1 2 →