Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division

被引：40

作者：

Wen, Wenyu ^{[1
,2
]}

Zhang, Mingjie ^{[3
,4
]}

机构：

[1] Fudan Univ, Inst Biomed Sci, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China

[2] Fudan Univ, Key Lab Metab & Mol Med, Shanghai Med Coll, Minist Educ,Dept Syst Biol Med,Sch Basic Med Sci, Shanghai 200032, Peoples R China

[3] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Div Life Sci, Kowloon, Hong Kong, Peoples R China

[4] Hong Kong Univ Sci & Technol, Ctr Syst Biol & Human Hlth, Kowloon, Hong Kong, Peoples R China

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2018年 / 430卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Protein complex assembly; Polarity proteins; Epithelial cell polarity; Asymmetric cell division; Par complex; MITOTIC SPINDLE ORIENTATION; HETEROTRIMERIC G-PROTEINS; GUANYLATE KINASE DOMAINS; TIGHT JUNCTION FORMATION; N-TERMINAL DOMAIN; DROSOPHILA NEUROBLASTS; ADHERENS JUNCTION; STRUCTURAL BASIS; BINDING-PROTEIN; APICAL DOMAIN;

D O I：

10.1016/j.jmb.2017.09.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asymmetric local concentration of protein complexes on distinct membrane regions is a fundamental property in numerous biological processes and is a hallmark of cell polarity. Evolutionarily conserved core polarity proteins form specific and dynamic networks to regulate the establishment and maintenance of cell polarity, as well as distinct polarity-driven cellular events. This review focuses on the molecular and structural basis governing regulated formation of several sets of core cell polarity regulatory complexes, as well as their functions in epithelial cell polarization and asymmetric cell division. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3504 / 3520

页数：17

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