Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use

被引：33

作者：

Maric, Stefano ^{[1
]}

Restin, Tanja ^{[2
,3
,4
]}

Muff, Julian Louis ^{[1
]}

Camargo, Simone Mafalda ^{[2
]}

Guglielmetti, Laura Chiara ^{[5
]}

Holland-Cunz, Stefan Gerhard ^{[6
]}

Crenn, Pascal ^{[7
]}

Vuille-dit-Bille, Raphael Nicolas ^{[2
,6
]}

机构：

[1] Univ Basel, Sch Med, CH-4001 Basel, Switzerland

[2] Univ Zurich, Inst Physiol, CH-8091 Zurich, Switzerland

[3] Univ Hosp Zurich, Dept Neonatol, Newborn Res Zurich, CH-8091 Zurich, Switzerland

[4] Univ Zurich, CH-8091 Zurich, Switzerland

[5] Cantonal Hosp Winterthur, Dept Visceral & Thorac Surg, CH-8400 Winterthur, Switzerland

[6] Univ Childrens Hosp Basel, Dept Pediat Surg, CH-4001 Basel, Switzerland

[7] Univ Paris Saclay, Hop Ambroise Pare, AP HP, Hepatogastroenterol & Nutr, F-92100 Boulogne, France

来源：

NUTRIENTS | 2021年 / 13卷 / 08期

关键词：

citrulline; amino acid supplementation; L-citrulline; glutamine; arginine; SHORT-BOWEL SYNDROME; PARENTERAL-NUTRITION DEPENDENCE; SIMPLE QUANTITATIVE MARKER; CONGENITAL HEART-SURGERY; MUSCLE PROTEIN-SYNTHESIS; CRITICALLY-ILL INFANTS; NITRIC-OXIDE SYNTHESIS; AMINO-ACID-ABSORPTION; LONG-TERM SURVIVAL; ORAL L-CITRULLINE;

D O I：

10.3390/nu13082794

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

L-Citrulline is a non-essential but still important amino acid that is released from enterocytes. Because plasma levels are reduced in case of impaired intestinal function, it has become a biomarker to monitor intestinal integrity. Moreover, oxidative stress induces protein citrullination, and antibodies against anti-citrullinated proteins are useful to monitor rheumatoid diseases. Citrullinated histones, however, may even predict a worse outcome in cancer patients. Supplementation of citrulline is better tolerated compared to arginine and might be useful to slightly improve muscle strength or protein balance. The following article shall provide an overview of L-citrulline properties and functions, as well as the current evidence for its use as a biomarker or as a therapeutic supplement.

引用

页数：29