31P NMR kinetic study of the tandem cleavage of phosphonate esters by bromotrimethylsilane

被引：8

作者：

Conibear, Anne C.

Lobb, Kevin A.

Kaye, Perry T. ^{[1
]}

机构：

[1] Rhodes Univ, Dept Chem, ZA-6140 Grahamstown, South Africa

来源：

TETRAHEDRON | 2010年 / 66卷 / 43期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

Phosphorus-31; NMR; Phosphonate esters; Kinetics; Bromotrimethylsilane; REDUCTOISOMERASE INHIBITORS; ANTIMALARIAL-DRUGS; BIOSYNTHESIS; CALIBRATION; PHOSPHATE; PATHWAY; PROBE;

D O I：

10.1016/j.tet.2010.08.058

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

H-1 and P-31 NMR methods have been used to access rate constants and activation parameters for each of the consecutive second-order silylation reactions involved in the overall transformation (1a -> 3a -> 4a), while computational optimisation of the rate constants obtained from the initial, linear phase of each reaction has permitted an excellent fit with the experimental data for the entire course of the reaction. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：8446 / 8449

页数：4

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