Long-Term Outcome of Patients with Spinal Dural Arteriovenous Fistula: The Dilemma of Delayed Diagnosis

被引:22
作者
Jablawi, F. [1 ]
Schubert, G. A. [2 ]
Dafotakis, M. [3 ]
Pons-Kuehnemann, J. [5 ]
Hans, F-J [4 ,6 ]
Mull, M. [1 ]
机构
[1] RWTH Aachen Univ Hosp, Dept Diagnost & Intervent Neuroradiol, Pauwelsstr 30, D-52074 Aachen, Germany
[2] RWTH Aachen Univ Hosp, Dept Neurosurg, Aachen, Germany
[3] RWTH Aachen Univ Hosp, Dept Neurol, Aachen, Germany
[4] Justus Liebig Univ Giessen, Dept Neurosurg, Giessen, Germany
[5] Justus Liebig Univ Giessen, Inst Med Informat, Med Stat, Giessen, Germany
[6] Paracelsus Kliniken, Dept Neurosurg, Osnabruck, Germany
关键词
MALFORMATIONS; SERIES;
D O I
10.3174/ajnr.A6372
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND AND PURPOSE: The impact of various radiologic and clinical features on the long-term outcome in spinal dural arteriovenous fistulas is still unclear; thus, they are the purpose of this study. MATERIALS AND METHODS: We retrospectively analyzed our medical data base for all patients treated for spinal dural arteriovenous fistula in our institution between 2006 and 2016. Patient age, neurologic status at the time of diagnosis, the duration of symptoms from onset to diagnosis, and follow-up information were evaluated. The extent of medullary T2WI hyperintensity, intramedullary contrast enhancement, and elongation of perimedullary veins on MR imaging at the time of diagnosis were additionally analyzed. RESULTS: Data for long-term outcome analysis were available in 40 patients with a mean follow-up of 52?months (median, 50.5?months; range, 3?159?months). The mean age at the time of diagnosis was 69.27 ? 9?years (median, 71 years; range, 53?84 years) with a male predominance (n = 32; 80%). The mean duration of symptoms was 20.2?months (median, 10?months; range, 1?120?months). Shorter duration of symptoms at the time of diagnosis was significantly correlated with better outcome of symptoms (P?<?.05). CONCLUSIONS: Spinal dural arteriovenous fistulas are characterized by interindividually variable clinical presentations, which make a determination of specific predictors for long-term outcome more difficult. Fast and sufficient diagnosis might result in a better outcome after treatment. The diagnosis of spinal dural arteriovenous fistula remains markedly delayed, reflecting an ongoing lack of knowledge and awareness among treating physicians of this rare-but-serious disease.
引用
收藏
页码:357 / 363
页数:7
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