Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways

被引：15

作者：

van Dyk, E. ^{[1
]}

Steenkamp, A. ^{[1
]}

Koekemoer, G. ^{[2
]}

Pretorius, P. J. ^{[1
]}

机构：

[1] North West Univ, Sch Phys & Chem Sci, Ctr Human Metabon, ZA-2520 Potchefstroom, South Africa

[2] North West Univ, Stat Consultat Serv, ZA-2520 Potchefstroom, South Africa

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 401卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Hereditary tyrosinemia; Base excision repair; Nucleotide excision repair; Comet assay; COMET ASSAY; DAMAGE; FUMARYLACETOACETATE; HOGG1;

D O I：

10.1016/j.bbrc.2010.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified comet assay to determine the effect of these metabolites on base- and nucleotide excision repair pathways. Our results indicate that the metabolites affected the repair mechanisms differently, since the metabolites had a bigger detrimental effect on BER than on NER. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：32 / 36

页数：5

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