Temporal stability of the dex/CRH test in patients with rapid-cycling bipolar I disorder: a pilot study

被引：4
作者：
Watson, S
Thompson, JM
Malik, N
Ferrier, IN
Young, AH
机构：
[1] Royal Victoria Infirm, Dept Psychiat, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[2] Univ Newcastle Upon Tyne, Royal Victoria Infirm, Stanley Res Ctr, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
来源：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 2005年 / 39卷 / 04期
关键词：
bipolar disorder; cortisol; dexamethasone-corticotropin releasing hormone; human; rapid-cycling;
D O I：
10.1111/j.1440-1614.2005.01560.x
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: To examine the hypothesis that hypothalamic-pituitary-adrenal (HPA) axis function is a trait abnormality in bipolar disorder. Method: We examined HPA axis function in a pilot study of five patients with rapid-cycling bipolar disorder in both relapse and remission using the dexamethasone/corticotropin releasing hormone (dex/CRH) test. Results: The cortisol response to the dex/CRH test correlated significantly between the 2 tests (r = 0.997; p < 0.0005). Conclusion: The data suggests that the cortisol response to the dex/CRH test is stable over time and independent of mood state.
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收藏
页码：244 / 247
页数：4
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