The role of bile acids and their TGR5 receptor in irritable bowel syndrome and diarrhoea

被引：5

作者：

Walters, Julian R. F. ^{[1
,2
]}

机构：

[1] Imperial Coll Healthcare NHS Trust, Dept Gastroenterol, London W12 0NN, England

[2] Hammersmith Hosp, Imperial Coll London, Div Digest Dis, London W12 0NN, England

来源：

DIGESTIVE AND LIVER DISEASE | 2021年 / 53卷 / 09期

关键词：

Irritable bowel syndrome; Functional diarrhoea; Bile acids; TGR5; MALABSORPTION; PREVALENCE; MICROBIOTA;

D O I：

10.1016/j.dld.2021.06.017

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This commentary looks at recent findings relating to bile acids in patients with irritable bowel syndrome with diarrhoea (IBS-D). Bile acid diarrhoea is recognised to be a frequent, treatable cause of chronic diarrhoea, with a clinical picture which overlaps IBS-D. In the study - by Wei and colleagues, a large proportion of IBS-D patients were shown to have increased faecal bile acids, and an increase in primary bile acids, reflecting changes in bacterial metabolism. Expression of the colonic membrane bile acid receptor, TGR5, was associated with faecal bile acids and the severity of symptoms. (C) 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：1118 / 1119

页数：2

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