Monoclinic zirconia nanoparticle-catalyzed regioselective synthesis of some novel substituted spirooxindoles through one-pot multicomponent reaction in a ball mill: A step toward green and sustainable chemistry

被引：16

作者：

Bajpai, Shivam ^{[1
]}

Singh, Sundaram ^{[1
]}

Srivastava, Vandana ^{[1
]}

机构：

[1] Indian Inst Technol BHU, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 16期

关键词：

Ball milling; isatin derivatives; m-ZrO2; nanoparticles; spirooxindoles; RECOVERABLE CATALYSTS; 3-COMPONENT SYNTHESIS; ORGANIC-SYNTHESIS; AQUEOUS-MEDIUM; DERIVATIVES; EFFICIENT; MICROWAVE; SUPPORT; SILICA; CARBON;

D O I：

10.1080/00397911.2017.1336244

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient, green as well as atom economical protocol for the synthesis of substituted spirooxindoles from m-ZrO2 NPs catalyzed multicomponent reaction of isatin derivatives with ethyl cyanoacetate and 1,3-dicarbonyl compounds in a ball mill has been established. Because of the simple and readily available starting materials, easy operation, and high bioactivity of substituted spirooxindoles, this strategy can be broadly applied to medicinal chemistry. The recyclability of the m-ZrO2 Nps catalyst is another emphasis of proposed methodology. [GRAPHICS]

引用

页码：1514 / 1525

页数：12

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