Amyloid β and Alzheimer disease therapeutics:: the devil may be in the details

被引：22

作者：

Cirrito, JR

Holtzman, DM

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Ctr Study Nervous Syst Injury, St Louis, MO 63110 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 03期

关键词：

D O I：

10.1172/JCI200319420

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alzheimer disease (AD) is characterized by the progressive accumulation of amyloid beta protein (Abeta) in areas of the brain serving cognitive functions such as memory and language. The first of two separate reports (see the related articles beginning on pages 415 and 440) reveals that intrinsic T cell reactivity to the self-antigen Abeta exists in many humans and increases with age. This finding has implications for the design of Abeta vaccines. The second report demonstrates that a number of FDA-approved nonsteroidal anti-inflammatory drugs are capable of lowering Abeta levels in mice. The work suggests that further testing of the therapeutic utility of these types of compounds for the potential treatment of AD is warranted.

引用

页码：321 / 323

页数：3

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