Synthesis of Readily Accessible Triazole-Linked Dimer Deoxynucleoside Phosphoramidite for Solid-Phase Oligonucleotide Synthesis

被引：11

作者：

Chandrasekhar, Srivari ^{[1
]}

Srihari, Pabbaraja ^{[1
]}

Nagesh, Chidalla ^{[1
]}

Kiranmai, Nayani ^{[1
]}

Nagesh, Narayana ^{[2
]}

Idris, M. Mohammed ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2010年 / 21期

关键词：

nucleotides; triazole; click; oligomer; solid-phase synthesis; MICROWAVE-ASSISTED SYNTHESIS; MODIFIED NUCLEOSIDES; THYMIDINE DIMERS; DNA; LINKAGE; ANALOGS; RNA;

D O I：

10.1055/s-0030-1258243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise preparation of triazole-linked deoxynucleoside phosphoramidite for its direct use in solid-phase oligonucleotide synthesis is reported. This dimer has successfully been utilized in solid-phase synthesis to make the 10- and 12-mer oligomers.

引用

页码：3710 / 3714

页数：5

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