Blood compatibility of poly[bis(trifluoroethoxy)phosphazene]

被引：0

作者：

Grunze, M ^{[1
]}

Welle, A ^{[1
]}

Tur, D ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Appl Phys Chem, Heidelberg, Germany

来源：

CONFERENCE PROCEEDINGS AT ANTEC '98: PLASTICS ON MY MIND, VOLS I-3: VOL I; PROCESSING, VOL II; SPECIAL AREAS, VOL III; MATERIALS | 1998年 / 44卷

关键词：

polyphosphazene; blood compatibility; protein adsorption; platelet adhesion;

D O I：

暂无

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

We developed a process to coat surfaces with Poly[bis(trifluoroethoxy)phosphazene] (PTFEP) [1] and tested the blood compatibility with Enzyme Linked Immunosorbent Assays (ELISA) and in vitro platelet adhesion experiments. We observed that the protein film adsorbed from human blood plasma on PTFEP exhibits a favorable composition with high amounts of albumin and low amounts of coagulation stimulating proteins (fibrinogen and others). Circular dichroism experiments revealed that fibrinogen does not denature on PTFEP to the extent found on other surfaces. We suggest that the trifluoroethanol moieties of PTFEP are responsible for these effects.

引用

页码：2713 / 2717

页数：5