Neospora caninum is considered one of the main causes of abortion in cattle, yet recent studies have also emphasised its relevance as an abortifacient in small ruminants. In order to gain deeper insight into the pathogenesis of ovine neosporosis, pregnant ewes were intravenously inoculated with 10(6) tachyzoites of the Nc-Spain7 isolate at days 40, 90 or 120 of gestation. Infection during the first term resulted in the death of all foetuses between days 19 and 21 post-infection, showing mainly necrotic lesions in foetal liver and the highest parasite DNA detection and burden in both placenta and foetal viscera. After infection at day 90, foetal death was also detected in all ewes, although later (34-48 days post-infection). In this group, lesions were mainly inflammatory. Foetal livers showed the lowest frequency of lesions, as well as the lowest parasite detection and burden. All ewes infected at day 120 delivered viable lambs, although 3 out of 9 showed weakness and recumbency. Neospora DNA was detected in all lambs but one, and parasite burden was similar to that observed in day 90 group. Lesions in this group showed more conspicuous infiltration of inflammatory cells and higher frequency in foetal brain and muscle when compared to both previous groups. These results highlight the crucial role that the stage of gestation plays on the course of ovine neosporosis, similar to that reported in bovine neosporosis, and open the doors to consider sheep as a valid model for exogenous transplacental transmission for ruminant neosporosis.
机构:
Univ Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Benavides, Julio
;
Collantes-Fernandez, Esther
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Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Collantes-Fernandez, Esther
;
Ferre, Ignacio
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Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Ferre, Ignacio
;
Perez, Valentin
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Univ Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Perez, Valentin
;
Campero, Carlos
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h-index: 0
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Inst Nacl Tecnol Agr, RA-7620 Balcarce, ArgentinaUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Campero, Carlos
;
Mota, Rinaldo
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Univ Fed Rural Pernambuco, Dept Vet Med, Recife, PE, BrazilUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Mota, Rinaldo
;
Innes, Elisabeth
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Moredun Res Inst, Edinburgh EH26 0PZ, Midlothian, ScotlandUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Innes, Elisabeth
;
Ortega-Mora, Luis M.
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Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Buxton, D
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Maley, SW
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UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Maley, SW
;
Thomson, KM
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UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Thomson, KM
;
Trees, AJ
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UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Trees, AJ
;
Innes, EA
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h-index: 0
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UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
机构:
Univ Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Benavides, Julio
;
Collantes-Fernandez, Esther
论文数: 0引用数: 0
h-index: 0
机构:
Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Collantes-Fernandez, Esther
;
Ferre, Ignacio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Ferre, Ignacio
;
Perez, Valentin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Perez, Valentin
;
Campero, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Inst Nacl Tecnol Agr, RA-7620 Balcarce, ArgentinaUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Campero, Carlos
;
Mota, Rinaldo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Rural Pernambuco, Dept Vet Med, Recife, PE, BrazilUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Mota, Rinaldo
;
Innes, Elisabeth
论文数: 0引用数: 0
h-index: 0
机构:
Moredun Res Inst, Edinburgh EH26 0PZ, Midlothian, ScotlandUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
Innes, Elisabeth
;
Ortega-Mora, Luis M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Complutense Madrid, SALUVET, Dept Anim Hlth, Fac Vet Sci, E-28040 Madrid, SpainUniv Leon, Fac Vet, Dept Sanidad Anim, Inst Ganaderia Montana,CSIC ULE, E-24071 Leon, Spain
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Buxton, D
;
Maley, SW
论文数: 0引用数: 0
h-index: 0
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Maley, SW
;
Thomson, KM
论文数: 0引用数: 0
h-index: 0
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Thomson, KM
;
Trees, AJ
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h-index: 0
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND
Trees, AJ
;
Innes, EA
论文数: 0引用数: 0
h-index: 0
机构:
UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLANDUNIV LIVERPOOL, LIVERPOOL SCH TROP MED, LIVERPOOL L3 5QA, MERSEYSIDE, ENGLAND